DegronMD

Uniprot ID: Q96EK7

Source protein: Constitutive coactivator of peroxisome proliferator-activated receptor gamma

Source gene: FAM120B

Class: DEG_SPOP_SBC_1

Location: 328:332

E3 ligase: SPOP

DEGRON score: 0.9894

ASA_SCORE: 71.72

COIL: 0.8452

CONS_SCORE: 0.4694

DSS_SCORE: 0.4639

HELIX: 0.053

FCONS_SCORE: 0.9461

RIG_SCORE: 0.7396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S333L	TCGA-06-5416	GBM	TCGA	VISTS	DEG_SPOP_SBC_1	0.3056
p.S332I	TCGA-17-Z027	LUAD	TCGA	VISTS	DEG_SPOP_SBC_1	0.7341
p.D334Y	TCGA-19-5956	GBM	TCGA	VISTS	DEG_SPOP_SBC_1	0.2778
p.A335T	TCGA-4Z-AA82	BLCA	TCGA	VISTS	DEG_SPOP_SBC_1	0.25
p.S330Y	TCGA-A5-A0G2	UCEC	TCGA	VISTS	DEG_SPOP_SBC_1	0.712
p.A335V	TCGA-D1-A103	UCEC	TCGA	VISTS	DEG_SPOP_SBC_1	0.25
p.A335V	DO42312	UCEC	ICGC	VISTS	DEG_SPOP_SBC_1	0.25
p.E336K	TCGA-DF-A2KU	UCEC	TCGA	VISTS	DEG_SPOP_SBC_1	0.2222
p.P330H	DO234239	ESAD	ICGC	VISTS	DEG_SPOP_SBC_1	0.7694
p.P319S	DO44469	KIRP	ICGC	VISTS	DEG_SPOP_SBC_1	0.5278
p.S342Y	DO41235	UCEC	ICGC	VISTS	DEG_SPOP_SBC_1	0.0556
p.F337V	SIDM00980	Gastric Carcinoma	GDSC	VISTS	DEG_SPOP_SBC_1	0.1944
p.F337V	23132-87	stomach	COSMIC	VISTS	DEG_SPOP_SBC_1	0.1944
p.K326Q	ACH-000215	Brain Cancer	CCLE	VISTS	DEG_SPOP_SBC_1	0.7222
p.G332D	KYSE-510	oesophagus	COSMIC	VISTS	DEG_SPOP_SBC_1	0.7198
p.G332D	KALS-1	central_nervous_system	COSMIC	VISTS	DEG_SPOP_SBC_1	0.7198
p.G332D	no-10	central_nervous_system	COSMIC	VISTS	DEG_SPOP_SBC_1	0.7198
p.G320D	no-10	central_nervous_system	COSMIC	VISTS	DEG_SPOP_SBC_1	0.1111
p.G320D	KYSE-510	oesophagus	COSMIC	VISTS	DEG_SPOP_SBC_1	0.1111
p.G320D	KALS-1	central_nervous_system	COSMIC	VISTS	DEG_SPOP_SBC_1	0.1111
p.F326V	23132-87	stomach	COSMIC	VISTS	DEG_SPOP_SBC_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_SPOP_SBC_1	2212:2216	VISTS	SPOP	0.6313	More...
P18583	Protein SON	DEG_SPOP_SBC_1	1642:1646	VISTS	SPOP	0.996	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	1680:1684	VISTS	SPOP	0.8674	More...
Q9UPS8	Ankyrin repeat domain-containing protein 26	DEG_SPOP_SBC_1	1632:1636	VISTS	SPOP	0.8911	More...
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	DEG_SPOP_SBC_1	328:332	VISTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons