DegronMD

Uniprot ID: Q8WUY3

Source protein: Protein prune homolog 2

Source gene: PRUNE2

Class: DEG_SPOP_SBC_1

Location: 1680:1684

E3 ligase: SPOP

DEGRON score: 0.8674

ASA_SCORE: 88.28

COIL: 0.891

CONS_SCORE: 0.4106

DSS_SCORE: 0.6886

HELIX: 0.0606

FCONS_SCORE: 1.0623

RIG_SCORE: 0.6739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1693S	TCGA-AA-3864	COAD	TCGA	VISTS	DEG_SPOP_SBC_1	0.0833
p.D1690G	TCGA-CG-5728	STAD	TCGA	VISTS	DEG_SPOP_SBC_1	0.1667
p.S1687Y	TCGA-ER-A195	SKCM	TCGA	VISTS	DEG_SPOP_SBC_1	0.25
p.S1691N	TCGA-FR-A726	SKCM	TCGA	VISTS	DEG_SPOP_SBC_1	0.1389
p.S1679C	DO48583	BLCA	ICGC	VISTS	DEG_SPOP_SBC_1	0.3056
p.S1679C	DO2401	BRCA	ICGC	VISTS	DEG_SPOP_SBC_1	0.3056
p.P1691L	DO228948	LICA	ICGC	VISTS	DEG_SPOP_SBC_1	0.1389
p.G1673C	DO45299	LIRI	ICGC	VISTS	DEG_SPOP_SBC_1	0.1389
p.P1681L	DO23633	LUAD	ICGC	VISTS	DEG_SPOP_SBC_1	0.7582
p.D1677N	DO229459	SKCA	ICGC	VISTS	DEG_SPOP_SBC_1	0.25
p.D1677N	SIDM00937	Oral Cavity Carcinoma	GDSC	VISTS	DEG_SPOP_SBC_1	0.25
p.D1677N	KM12	large_intestine	COSMIC	VISTS	DEG_SPOP_SBC_1	0.25
p.P1691S	DO42033	UCEC	ICGC	VISTS	DEG_SPOP_SBC_1	0.1389
p.S1670Y	SIDM00656	Burkitt's Lymphoma	GDSC	VISTS	DEG_SPOP_SBC_1	0.5
p.S1670Y	ACH-000944	Lymphoma	CCLE	VISTS	DEG_SPOP_SBC_1	0.5
p.S1670Y	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	VISTS	DEG_SPOP_SBC_1	0.5
p.D1688N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VISTS	DEG_SPOP_SBC_1	0.2222
p.D1688N	ACH-000929	Lung Cancer	CCLE	VISTS	DEG_SPOP_SBC_1	0.2222
p.D1688N	NCI-H2110	lung	COSMIC	VISTS	DEG_SPOP_SBC_1	0.2222
p.S1684R	ACH-001751	Sarcoma	CCLE	VISTS	DEG_SPOP_SBC_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_SPOP_SBC_1	2212:2216	VISTS	SPOP	0.6313	More...
P18583	Protein SON	DEG_SPOP_SBC_1	1642:1646	VISTS	SPOP	0.996	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	1680:1684	VISTS	SPOP	0.8674	More...
Q9UPS8	Ankyrin repeat domain-containing protein 26	DEG_SPOP_SBC_1	1632:1636	VISTS	SPOP	0.8911	More...
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	DEG_SPOP_SBC_1	328:332	VISTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons