DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PTPPKS
Uniprot ID:
P18583
Source protein:
Protein SON
Source gene:
SON
Class:
DEG_SCF_FBW7_1
Location:
2162:2167
E3 ligase:
FBXW7
DEGRON score:
0.9814
ASA_SCORE:
83.8
COIL:
0.855
CONS_SCORE:
0.7921
DSS_SCORE:
0.4954
HELIX:
0.0868
FCONS_SCORE:
0.9962
RIG_SCORE:
0.6669
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.F2153L
TCGA-B5-A1MR
UCEC
TCGA
PTPPKS
DEG_SCF_FBW7_1
0.0833
p.F2153L
DO41758
UCEC
ICGC
PTPPKS
DEG_SCF_FBW7_1
0.0833
Drug responses associated with SON mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPPKS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P18583
Protein SON
DEG_SCF_FBW7_1
2162:2167
PTPPKS
FBXW7
0.9814
More...