DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_SPOP_SBC_1

Location: 320:324

E3 ligase: SPOP

DEGRON score: 0.9507

ASA_SCORE: 85.7

COIL: 0.9406

CONS_SCORE: 0.7566

DSS_SCORE: 0.6888

HELIX: 0.0188

FCONS_SCORE: 0.9701

RIG_SCORE: 0.6506

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P320R	TCGA-BA-6873	HNSC	TCGA	PSTST	DEG_SPOP_SBC_1	0.7512
p.P320R	DO14242	HNSC	ICGC	PSTST	DEG_SPOP_SBC_1	0.7512
p.W320L	DO229036	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	0.7015
p.T325A	TCGA-A5-A0G2	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	0.3056
p.T325A	DO41235	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	0.3056
p.A319S	DO229006	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	0.3056
p.M326I	SIDM01118	Small Cell Lung Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	0.2778
p.M326I	SIDM00710	Small Cell Lung Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	0.2778
p.M326I	SIDM01759	Hodgkin's Lymphoma	GDSC	PSTST	DEG_SPOP_SBC_1	0.2778
p.G316D	ACH-000997	Colon/Colorectal Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	0.2222
p.G316D	HCT-15	large_intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	0.2222
p.E315K	TCGA-78-7539	LUAD	TCGA	PSTST	DEG_SPOP_SBC_1	0.1944
p.E315K	DO26210	LUAD	ICGC	PSTST	DEG_SPOP_SBC_1	0.1944
p.S331L	TCGA-DK-A6B6	BLCA	TCGA	PSTST	DEG_SPOP_SBC_1	0.1389
p.S331L	DO48576	BLCA	ICGC	PSTST	DEG_SPOP_SBC_1	0.1389

Showing 1 to 15 of 15 entries

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Drug responses associated with SON mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PSTST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JQC9	A-kinase anchor protein 4	DEG_SPOP_SBC_1	131:135	PSTST	SPOP	0.6428	More...
Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	DEG_SPOP_SBC_1	1053:1057	PSTST	SPOP	0.8236	More...
Q99856	AT-rich interactive domain-containing protein 3A	DEG_SPOP_SBC_1	583:587	PSTST	SPOP	0.9473	More...
Q5T1B0	Axonemal dynein light chain domain-containing protein 1	DEG_SPOP_SBC_1	872:876	PSTST	SPOP	0.9934	More...
Q6PI47	BTB/POZ domain-containing protein KCTD18	DEG_SPOP_SBC_1	281:285	PSTST	SPOP	0.6017	More...
Q99715	Collagen alpha-1	DEG_SPOP_SBC_1	1855:1859	PSTST	SPOP	0.7973	More...
Q96PD2	Discoidin, CUB and LCCL domain-containing protein 2	DEG_SPOP_SBC_1	696:700	PSTST	SPOP	0.9984	More...
Q96EP1	E3 ubiquitin-protein ligase CHFR	DEG_SPOP_SBC_1	177:181	PSTST	SPOP	0.9967	More...
Q8TC56	Golgi associated RAB2 interactor protein 3	DEG_SPOP_SBC_1	250:254	PSTST	SPOP	0.9921	More...
Q00056	Homeobox protein Hox-A4	DEG_SPOP_SBC_1	310:314	PSTST	SPOP	0.9405	More...
Q96G42	Kelch domain-containing protein 7B	DEG_SPOP_SBC_1	29:33	PSTST	SPOP	0.9278	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	966:970	PSTST	SPOP	0.9963	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1129:1133	PSTST	SPOP	0.9421	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1170:1174	PSTST	SPOP	0.9246	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1211:1215	PSTST	SPOP	0.9576	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1252:1256	PSTST	SPOP	0.941	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1293:1297	PSTST	SPOP	0.8982	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1416:1420	PSTST	SPOP	0.9919	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1457:1461	PSTST	SPOP	0.7823	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1539:1543	PSTST	SPOP	0.9907	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6882:6886	PSTST	SPOP	0.8449	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	506:510	PSTST	SPOP	0.6935	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	1809:1813	PSTST	SPOP	0.9674	More...
Q9BZF3	Oxysterol-binding protein-related protein 6	DEG_SPOP_SBC_1	200:204	PSTST	SPOP	0.9954	More...
Q7Z3K3	Pogo transposable element with ZNF domain	DEG_SPOP_SBC_1	253:257	PSTST	SPOP	0.9085	More...

Showing 1 to 25 of 35 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTST

Degron related mutations and impact score

Drug responses associated with SON mutations

All proteins holding degron of PSTST