DegronMD - Q5JQC9(AKAP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E291A	TCGA-13-0807	OV	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.1111
p.G124C	TCGA-A5-A0G1	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1389
p.S130R	TCGA-AP-A0LM	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.3056
p.D314E	TCGA-AU-6004	COAD	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.0833
p.K299I	TCGA-AX-A2HC	UCEC	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation altering degron motif	0.7531
p.L302I	TCGA-B5-A0JY	UCEC	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation altering degron motif	0.6063
p.G141V	TCGA-EE-A3AC	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.F301L	TCGA-EO-A22X	UCEC	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation altering degron motif	0.587
p.R294M	TCGA-EY-A1GF	UCEC	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.1944
p.E305K	TCGA-FI-A2D0	UCEC	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation altering degron motif	0.7022
p.K139E	TCGA-FR-A729	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	131:135	Mutation substituting flanking lysine	0.3333
p.H138Y	TCGA-VQ-A924	STAD	TCGA	PSTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.25
p.E144D	DO225089	BRCA	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.D305E	DO7780	COAD	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation altering degron motif	0.6758
p.H139N	DO8264	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation substituting flanking lysine	0.3333
p.N299S	DO224628	COCA	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation altering degron motif	0.7069
p.S313R	DO229036	LICA	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.1111
p.S313R	ACH-001674	Neuroblastoma	CCLE	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.1111
p.S313R	TGW	autonomic ganglia	COSMIC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.1111
p.E135V	DO229052	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7693
p.G132E	DO220877	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7199
p.G132E	DO222363	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7199
p.E135K	DO220877	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7022
p.E137K	DO36881	READ	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2778
p.Q310K	DO46819	RECA	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.1944
p.G132V	DO37631	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7532
p.K130E	DO48618	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.3056
p.H129Y	DO51795	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2778
p.A141S	DO51761	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.S121R	DO43306	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.L293I	DO43041	UCEC	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation blocking phosphorylation signal	0.6111
p.K290I	DO41572	UCEC	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.0833
p.F292L	DO43907	UCEC	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.1389
p.E296K	DO43891	UCEC	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.25
p.S310R	SIDM01323	Oral Cavity Carcinoma	GDSC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation rewiring degron network	0.1944
p.S301R	ACH-000732	Head and Neck Cancer	CCLE	KSFLYSE	LIG_APCC_ABBAyCdc20_2	299:305	Mutation altering degron motif	0.7427

Kaplan plot for AKAP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP4

UniProt ID: Q5JQC9

Entrez ID: 8852

Protein name: A-kinase anchor protein 4 (AKAP-4) (A-kinase anchor protein 82 kDa) (AKAP 82) (hAKAP82) (Major sperm fibrous sheath protein) (HI) (Protein kinase A-anchoring protein 4) (PRKA4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKAP4 in