DegronMD

Uniprot ID: Q5JQC9

Source protein: A-kinase anchor protein 4

Source gene: AKAP4

Class: LIG_APCC_ABBAyCdc20_2

Location: 299:305

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9962

ASA_SCORE: 78.9143

COIL: 0.4583

CONS_SCORE: 0.8731

DSS_SCORE: 0.5677

HELIX: 0.3799

FCONS_SCORE: 1.4013

RIG_SCORE: 0.7259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E291A	TCGA-13-0807	OV	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D314E	TCGA-AU-6004	COAD	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.K299I	TCGA-AX-A2HC	UCEC	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.7531
p.L302I	TCGA-B5-A0JY	UCEC	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.6063
p.F301L	TCGA-EO-A22X	UCEC	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.587
p.R294M	TCGA-EY-A1GF	UCEC	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E305K	TCGA-FI-A2D0	UCEC	TCGA	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.7022
p.D305E	DO7780	COAD	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.6758
p.N299S	DO224628	COCA	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.7069
p.S313R	DO229036	LICA	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S313R	ACH-001674	Neuroblastoma	CCLE	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S313R	TGW	autonomic_ganglia	COSMIC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q310K	DO46819	RECA	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.L293I	DO43041	UCEC	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.6111
p.K290I	DO41572	UCEC	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.F292L	DO43907	UCEC	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E296K	DO43891	UCEC	ICGC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.25
p.S310R	SIDM01323	Oral Cavity Carcinoma	GDSC	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.S301R	ACH-000732	Head and Neck Cancer	CCLE	KSFLYSE	LIG_APCC_ABBAyCdc20_2	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JQC9	A-kinase anchor protein 4	LIG_APCC_ABBAyCdc20_2	299:305	KSFLYSE	APC,CDC20,FZR1	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons