DegronMD - Q5T1B0(AXDND1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K90N	TCGA-05-4382	LUAD	TCGA	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation altering degron motif	0.5806
p.K90N	DO24900	LUAD	ICGC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation altering degron motif	0.5806
p.W101R	TCGA-05-4410	LUAD	TCGA	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.0833
p.W101R	DO25426	LUAD	ICGC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.0833
p.A868V	TCGA-AJ-A23O	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.A868V	DO43290	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.K23N	TCGA-AX-A05Z	UCEC	TCGA	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation substituting flanking lysine	0.1667
p.K23N	DO40884	UCEC	ICGC	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation substituting flanking lysine	0.1667
p.L80S	TCGA-B5-A11G	UCEC	TCGA	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.1667
p.L80S	DO43514	UCEC	ICGC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.1667
p.K878M	TCGA-CV-5973	HNSC	TCGA	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2778
p.K878M	DO15014	HNSC	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2778
p.E863K	TCGA-D9-A1JW	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0833
p.E863K	TCGA-D9-A6EC	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0833
p.E863K	TCGA-FR-A726	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0833
p.E863K	DO37786	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0833
p.E863K	DO50291	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0833
p.E863K	DO48665	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0833
p.D98Y	TCGA-DA-A1IB	SKCM	TCGA	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.1667
p.D98Y	DO38033	SKCM	ICGC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.1667
p.N12H	TCGA-E6-A1LX	UCEC	TCGA	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.6312
p.N12H	DO41020	UCEC	ICGC	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.6312
p.P872S	TCGA-EE-A2GC	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	872:876	Mutation altering degron motif	0.6752
p.P872S	DO37839	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation altering degron motif	0.6752
p.P83S	TCGA-EE-A3J8	SKCM	TCGA	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.25
p.P83S	DO47276	SKCM	ICGC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.25
p.W101C	TCGA-EP-A2KC	LIHC	TCGA	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.0833
p.W101C	DO22966	LIHC	ICGC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.0833
p.K20E	TCGA-FD-A3B7	BLCA	TCGA	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation substituting flanking lysine	0.25
p.K20E	DO572	BLCA	ICGC	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation substituting flanking lysine	0.25
p.A868T	DO1155	BRCA	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.A868T	SIDM01134	Small Cell Lung Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.A868T	SIDM00881	Breast Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.A868T	SIDM01113	Other Sarcomas	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.A868T	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.A868T	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.A868T	SIDM00079	Ovarian Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.A868T	SIDM01560	Rhabdomyosarcoma	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.S875Y	DO7801	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation altering degron motif	0.712
p.R883Q	DO233855	GACA	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.1389
p.R883Q	DO222753	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.1389
p.S19I	DO229029	LICA	ICGC	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.1667
p.T16K	DO229264	THCA	ICGC	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.25
p.R867S	DO229234	THCA	ICGC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.1944
p.T9I	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.7078
p.T9I	ACH-000561	Esophageal Cancer	CCLE	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.7078
p.T9I	T-T	oesophagus	COSMIC	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.7078
p.T88A	SIDM00683	Prostate Carcinoma	GDSC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation altering degron motif	0.7139
p.T88A	ACH-000977	lymph node	CCLE	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation altering degron motif	0.7139
p.E862K	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0556
p.E862K	ACH-000697	Lymphoma	CCLE	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0556
p.E862K	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0556
p.E879K	SIDM00007	Other Solid Cancers	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.E879K	ACH-001550	Skin Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.E879K	MCC13	skin	COSMIC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.P89Q	SIDM00569	Osteosarcoma	GDSC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation altering degron motif	0.7035
p.P89Q	ACH-002178	Bone Cancer	CCLE	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation altering degron motif	0.7035
p.P89Q	NY	bone	COSMIC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation altering degron motif	0.7035
p.D98H	SIDM00589	Oral Cavity Carcinoma	GDSC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.1667
p.D98H	ACH-000778	Head and Neck Cancer	CCLE	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.1667
p.D98H	HSC-3	upper aerodigestive tract	COSMIC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.1667
p.G886V	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0556
p.G886V	ACH-000893	Lung Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0556
p.G886V	NCI-H1651	lung	COSMIC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.0556
p.R883L	SIDM01097	Other Solid Cancers	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.1389
p.R883L	ACH-001193	Bone Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.1389
p.R883L	SK-PN-DW	bone	COSMIC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.1389
p.E879G	SIDM00878	Breast Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.E879G	ACH-000930	Breast Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.E879G	HCC1569	breast	COSMIC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.C76F	SIDM00006	Other Solid Cancers	GDSC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.0556
p.C76F	ACH-001552	Skin Cancer	CCLE	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.0556
p.C76F	MCC26	skin	COSMIC	IKTPKGT	DEG_SCF_FBW7_1	86:92	Mutation rewiring degron network	0.0556
p.K21Q	SIDM00534	Colorectal Carcinoma	GDSC	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation substituting flanking lysine	0.2222
p.K21Q	ACH-000986	Colon/Colorectal Cancer	CCLE	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation substituting flanking lysine	0.2222
p.K21Q	HT-115	large intestine	COSMIC	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation substituting flanking lysine	0.2222
p.E879D	SIDM01611	Endometrial Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.E879D	ACH-000996	Endometrial/Uterine Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.S17Y	ACH-001699	Head and Neck Cancer	CCLE	PSTPLNS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AXDND1

UniProt ID: Q5T1B0

Entrez ID: 126859

Protein name: Axonemal dynein light chain domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AXDND1 in