DegronMD

Uniprot ID: Q5T1B0

Source protein: Axonemal dynein light chain domain-containing protein 1

Source gene: AXDND1

Class: DEG_SCF_FBW7_1

Location: 7:13

E3 ligase: FBXW7

DEGRON score: 0.9676

ASA_SCORE: 96.0143

COIL: 0.9586

CONS_SCORE: 0.3144

DSS_SCORE: 0.7199

HELIX: 0.026

FCONS_SCORE: 0.7865

RIG_SCORE: 0.6014

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K23N	TCGA-AX-A05Z	UCEC	TCGA	PSTPLNS	DEG_SCF_FBW7_1	0.1667
p.K23N	DO40884	UCEC	ICGC	PSTPLNS	DEG_SCF_FBW7_1	0.1667
p.N12H	TCGA-E6-A1LX	UCEC	TCGA	PSTPLNS	DEG_SCF_FBW7_1	0.6312
p.N12H	DO41020	UCEC	ICGC	PSTPLNS	DEG_SCF_FBW7_1	0.6312
p.K20E	TCGA-FD-A3B7	BLCA	TCGA	PSTPLNS	DEG_SCF_FBW7_1	0.25
p.K20E	DO572	BLCA	ICGC	PSTPLNS	DEG_SCF_FBW7_1	0.25
p.S19I	DO229029	LICA	ICGC	PSTPLNS	DEG_SCF_FBW7_1	0.1667
p.T16K	DO229264	THCA	ICGC	PSTPLNS	DEG_SCF_FBW7_1	0.25
p.T9I	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PSTPLNS	DEG_SCF_FBW7_1	0.7078
p.T9I	ACH-000561	Esophageal Cancer	CCLE	PSTPLNS	DEG_SCF_FBW7_1	0.7078
p.T9I	T-T	oesophagus	COSMIC	PSTPLNS	DEG_SCF_FBW7_1	0.7078
p.K21Q	SIDM00534	Colorectal Carcinoma	GDSC	PSTPLNS	DEG_SCF_FBW7_1	0.2222
p.K21Q	ACH-000986	Colon/Colorectal Cancer	CCLE	PSTPLNS	DEG_SCF_FBW7_1	0.2222
p.K21Q	HT-115	large_intestine	COSMIC	PSTPLNS	DEG_SCF_FBW7_1	0.2222
p.S17Y	ACH-001699	Head and Neck Cancer	CCLE	PSTPLNS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T1B0	Axonemal dynein light chain domain-containing protein 1	DEG_SCF_FBW7_1	7:13	PSTPLNS	FBXW7	0.9676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons