DegronMD

Uniprot ID: Q5T1B0

Source protein: Axonemal dynein light chain domain-containing protein 1

Source gene: AXDND1

Class: DEG_SCF_FBW7_1

Location: 86:92

E3 ligase: FBXW7

DEGRON score: 0.7694

ASA_SCORE: 91.2143

COIL: 0.9113

CONS_SCORE: 0.3549

DSS_SCORE: 0.4257

HELIX: 0.0207

FCONS_SCORE: 1.0081

RIG_SCORE: 0.7047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K90N	TCGA-05-4382	LUAD	TCGA	IKTPKGT	DEG_SCF_FBW7_1	0.5806
p.K90N	DO24900	LUAD	ICGC	IKTPKGT	DEG_SCF_FBW7_1	0.5806
p.W101R	TCGA-05-4410	LUAD	TCGA	IKTPKGT	DEG_SCF_FBW7_1	0.0833
p.W101R	DO25426	LUAD	ICGC	IKTPKGT	DEG_SCF_FBW7_1	0.0833
p.L80S	TCGA-B5-A11G	UCEC	TCGA	IKTPKGT	DEG_SCF_FBW7_1	0.1667
p.L80S	DO43514	UCEC	ICGC	IKTPKGT	DEG_SCF_FBW7_1	0.1667
p.D98Y	TCGA-DA-A1IB	SKCM	TCGA	IKTPKGT	DEG_SCF_FBW7_1	0.1667
p.D98Y	DO38033	SKCM	ICGC	IKTPKGT	DEG_SCF_FBW7_1	0.1667
p.P83S	TCGA-EE-A3J8	SKCM	TCGA	IKTPKGT	DEG_SCF_FBW7_1	0.25
p.P83S	DO47276	SKCM	ICGC	IKTPKGT	DEG_SCF_FBW7_1	0.25
p.W101C	TCGA-EP-A2KC	LIHC	TCGA	IKTPKGT	DEG_SCF_FBW7_1	0.0833
p.W101C	DO22966	LIHC	ICGC	IKTPKGT	DEG_SCF_FBW7_1	0.0833
p.T88A	SIDM00683	Prostate Carcinoma	GDSC	IKTPKGT	DEG_SCF_FBW7_1	0.7139
p.T88A	ACH-000977	lymph_node	CCLE	IKTPKGT	DEG_SCF_FBW7_1	0.7139
p.P89Q	SIDM00569	Osteosarcoma	GDSC	IKTPKGT	DEG_SCF_FBW7_1	0.7035
p.P89Q	ACH-002178	Bone Cancer	CCLE	IKTPKGT	DEG_SCF_FBW7_1	0.7035
p.P89Q	NY	bone	COSMIC	IKTPKGT	DEG_SCF_FBW7_1	0.7035
p.D98H	SIDM00589	Oral Cavity Carcinoma	GDSC	IKTPKGT	DEG_SCF_FBW7_1	0.1667
p.D98H	ACH-000778	Head and Neck Cancer	CCLE	IKTPKGT	DEG_SCF_FBW7_1	0.1667
p.D98H	HSC-3	upper_aerodigestive_tract	COSMIC	IKTPKGT	DEG_SCF_FBW7_1	0.1667
p.C76F	SIDM00006	Other Solid Cancers	GDSC	IKTPKGT	DEG_SCF_FBW7_1	0.0556
p.C76F	ACH-001552	Skin Cancer	CCLE	IKTPKGT	DEG_SCF_FBW7_1	0.0556
p.C76F	MCC26	skin	COSMIC	IKTPKGT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T1B0	Axonemal dynein light chain domain-containing protein 1	DEG_SCF_FBW7_1	86:92	IKTPKGT	FBXW7	0.7694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons