DegronMD - Q9ULU4(ZMYND8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T770S	TCGA-56-7222	LUSC	TCGA	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1667
p.T770S	TCGA-56-7222	LUSC	TCGA	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1389
p.T770M	TCGA-AA-A02R	COAD	TCGA	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1667
p.T770M	TCGA-AA-A02R	COAD	TCGA	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1389
p.S882L	TCGA-AC-A23H	BRCA	TCGA	PSTST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7667
p.S882L	TCGA-CR-7388	HNSC	TCGA	PSTST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7667
p.D736Y	TCGA-AP-A051	UCEC	TCGA	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.1389
p.A885T	TCGA-AX-A1CE	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.A885T	TCGA-E6-A1LX	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.A885T	HPAC	pancreas	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.P778L	TCGA-B5-A0KB	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7582
p.P778L	TCGA-FD-A5BT	BLCA	TCGA	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7582
p.A890T	TCGA-B5-A11E	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1389
p.M423T	TCGA-BG-A221	UCEC	TCGA	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.7423
p.E779D	TCGA-D9-A6EC	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.6758
p.P777L	TCGA-DA-A1HW	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7582
p.P777S	TCGA-DA-A1HW	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.6752
p.L869Q	TCGA-DI-A1NO	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0556
p.P767S	TCGA-EE-A3J3	SKCM	TCGA	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.25
p.P767S	TCGA-EE-A3J3	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.0556
p.P767S	TCGA-GF-A6C9	SKCM	TCGA	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.25
p.P767S	TCGA-GF-A6C9	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.0556
p.D422H	TCGA-FD-A3SR	BLCA	TCGA	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.7688
p.R744W	TCGA-HU-A4GQ	STAD	TCGA	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.8634
p.P758L	DO44032	BLCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation altering degron motif	0.6471
p.P758L	DO41097	UCEC	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation altering degron motif	0.6471
p.S756C	DO218173	BRCA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation blocking phosphorylation signal	0.6111
p.S756C	DO218173	BRCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation blocking phosphorylation signal	0.75
p.S756C	DO218173	BRCA	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation blocking phosphorylation signal	0.6389
p.M434I	DO5731	BRCA	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.2222
p.V787I	DO223732	CESC	ICGC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1667
p.R423Q	DO223732	CESC	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.7329
p.R423Q	DO32247	OV	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.7329
p.A878T	DO8432	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.3056
p.A878T	DO41644	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.3056
p.A878T	TGBC11TKB	stomach	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.3056
p.V752A	DO227999	COCA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.V752A	DO227999	COCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1944
p.V752A	DO227999	COCA	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.3056
p.V752A	DO229013	COCA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.V752A	DO229013	COCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1944
p.V752A	DO229013	COCA	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.3056
p.V752A	DO229016	COCA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.V752A	DO229016	COCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1944
p.V752A	DO229016	COCA	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.3056
p.V752A	DO233628	GACA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.V752A	DO233628	GACA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1944
p.V752A	DO233628	GACA	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.3056
p.V752A	DO229346	LAML	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.V752A	DO229346	LAML	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1944
p.V752A	DO229346	LAML	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.3056
p.V752A	DO229353	LAML	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.V752A	DO229353	LAML	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1944
p.V752A	DO229353	LAML	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.3056
p.V752A	DO228941	LICA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.V752A	DO228941	LICA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1944
p.V752A	DO228941	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.3056
p.V752A	DO228947	LICA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.V752A	DO228947	LICA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1944
p.V752A	DO228947	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.3056
p.V752A	DO231102	LUSC	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.V752A	DO231102	LUSC	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1944
p.V752A	DO231102	LUSC	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.3056
p.G893E	DO234265	ESAD	ICGC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0556
p.R422L	DO233198	GACA	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.7316
p.A869T	DO233724	GACA	ICGC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0556
p.T778N	DO233869	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.5944
p.T784M	DO14329	HNSC	ICGC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.25
p.T784M	ACH-000489	Colon/Colorectal Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.25
p.T784M	SW1116	large intestine	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.25
p.P430L	DO16335	KIRC	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6471
p.P430L	DO51407	PRAD	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6471
p.Q740K	DO229024	LICA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.25
p.Q740K	DO229024	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1389
p.G421V	DO25528	LUAD	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.3056
p.T750S	DO26842	LUSC	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7116
p.T750S	DO26842	LUSC	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.7116
p.S425F	DO220878	MELA	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.7982
p.S425F	DO37839	SKCM	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.7982
p.L763F	DO222868	MELA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation altering degron motif	0.587
p.R431H	DO51407	PRAD	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.3056
p.D741Y	DO47120	RECA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.D741Y	DO47120	RECA	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1667
p.A791P	DO219881	SKCA	ICGC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.0556
p.A791P	DO218884	SKCA	ICGC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.0556
p.K882M	DO50291	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.8062
p.E759D	DO50291	SKCM	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation altering degron motif	0.5647
p.P747S	DO48652	SKCM	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6752
p.P747S	DO48652	SKCM	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.6752
p.P747S	DO51254	SKCM	ICGC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6752
p.P747S	DO51254	SKCM	ICGC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.6752
p.P757S	DO38129	SKCM	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation altering degron motif	0.6752
p.P757L	DO38129	SKCM	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation altering degron motif	0.6471
p.P761Q	DO229242	THCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation altering degron motif	0.7035
p.G887V	DO229242	THCA	ICGC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2222
p.S780N	DO219784	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7069
p.A870T	DO41644	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0833
p.A877T	DO42608	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.D889N	DO41235	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1667
p.E422D	SIDM01034	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00586	Hepatocellular Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00434	Plasma Cell Myeloma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01020	Plasma Cell Myeloma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00425	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00321	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00234	Other Solid Cancers	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01151	Hepatocellular Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00617	Hepatocellular Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00367	Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00291	Melanoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01144	Gastric Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00267	Biliary Tract Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00466	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00619	Thyroid Gland Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00351	Oral Cavity Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00383	Gastric Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00599	Osteosarcoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00487	Colorectal Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00292	Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01180	Hepatocellular Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00294	Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00564	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00239	Kidney Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00580	Acute Myeloid Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00397	Acute Myeloid Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00549	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01217	Other Blood Cancers	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00560	Gastric Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00289	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00233	T-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00316	Glioblastoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00503	Gastric Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00603	Head and Neck Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01033	Bladder Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01695	Acute Myeloid Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01735	Biliary Tract Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01617	Endometrial Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01470	Acute Myeloid Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01460	Glioma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01320	Pancreatic Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01578	Bladder Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00008	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00170	Head and Neck Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01611	Endometrial Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00158	Glioblastoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01573	Plasma Cell Myeloma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01432	Kidney Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01575	Plasma Cell Myeloma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01450	Gastric Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01433	Kidney Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01378	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01685	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM00164	Biliary Tract Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01559	Melanoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01662	Plasma Cell Myeloma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.E422D	SIDM01618	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.6758
p.M438I	SIDM00107	Melanoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation blocking phosphorylation signal	0.5556
p.M438I	UACC-62	skin	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation blocking phosphorylation signal	0.5556
p.G750R	SIDM00181	Bladder Carcinoma	GDSC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7568
p.G750R	SIDM00181	Bladder Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.7568
p.G750R	LB831-BLC	urinary tract	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7568
p.G750R	LB831-BLC	urinary tract	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.7568
p.S749A	SIDM00274	Gastric Carcinoma	GDSC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6477
p.S749A	SIDM00274	Gastric Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.7588
p.S749A	GCIY	stomach	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6477
p.S749A	GCIY	stomach	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.7588
p.D733E	SIDM00490	Glioma	GDSC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.0556
p.D733E	Becker	central nervous system	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.0556
p.A779T	ACH-000270	Pancreatic Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7139
p.A779T	ACH-001098	Pancreatic Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7139
p.A779T	HPAC	pancreas	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7139
p.T749M	ACH-000493	Liver Cancer	CCLE	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T749M	ACH-000493	Liver Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.7423
p.T749M	ACH-000967	Colon/Colorectal Cancer	CCLE	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T749M	ACH-000967	Colon/Colorectal Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.7423
p.T749M	ACH-001199	Colon/Colorectal Cancer	CCLE	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T749M	ACH-001199	Colon/Colorectal Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.7423
p.T749M	SNU-423	liver	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T749M	SNU-423	liver	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.7423
p.T749M	SNU-C2B	large intestine	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T749M	SNU-C2B	large intestine	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.7423
p.N778S	ACH-000519	Leukemia	CCLE	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7069
p.N778S	ACH-002216	Leukemia	CCLE	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7069
p.N778S	BE-13	haematopoietic and lymphoid tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7069
p.S776L	ACH-000529	Non-Cancerous	CCLE	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.3056
p.T788M	ACH-000900	Lung Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1389
p.T788M	NCI-H23	lung	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1389
p.A873T	ACH-000949	Gastric Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	879:883	Mutation substituting flanking lysine	0.2778
p.A873T	TGBC11TKB	stomach	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation substituting flanking lysine	0.2778
p.A784T	ACH-000952	Prostate Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.25
p.A784T	HPAC	pancreas	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.25
p.A775T	ACH-000962	Ovarian Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.2778
p.A775T	OC-314	ovary	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.2778
p.S889N	ACH-000979	Prostate Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1667
p.G438S	ACH-000999	Colon/Colorectal Cancer	CCLE	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation blocking phosphorylation signal	0.5556
p.G438S	SNU-1040	large intestine	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation blocking phosphorylation signal	0.5556
p.R870Q	ACH-001461	Colon/Colorectal Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0833
p.R418Q	ACH-001569	Skin Cancer	CCLE	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.2222
p.L421W	ACH-001804	Liposarcoma	CCLE	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.3056
p.Q739H	ACH-002199	Kidney Cancer	CCLE	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation substituting flanking lysine	0.3333
p.Q739H	ACH-002199	Kidney Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation substituting flanking lysine	0.2222
p.Q739H	SN12C	kidney	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation substituting flanking lysine	0.3333
p.Q739H	SN12C	kidney	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation substituting flanking lysine	0.2222
p.G414A	ACH-002317	Leukemia	CCLE	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.1111
p.G414A	YT	haematopoietic and lymphoid tissue	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.1111
p.A789T	NCI-H441	lung	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1111
p.G743R	LB831-BLC	urinary tract	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7568
p.T754M	SNU-423	liver	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation blocking phosphorylation signal	0.6667
p.T754M	SNU-423	liver	COSMIC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation blocking phosphorylation signal	0.6944
p.T754M	SNU-423	liver	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation blocking phosphorylation signal	0.6944
p.T754M	SNU-C2B	large intestine	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation blocking phosphorylation signal	0.6667
p.T754M	SNU-C2B	large intestine	COSMIC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation blocking phosphorylation signal	0.6944
p.T754M	SNU-C2B	large intestine	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation blocking phosphorylation signal	0.6944
p.Q891H	SN12C	kidney	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1111
p.A770T	OC-314	ovary	COSMIC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1667
p.A770T	OC-314	ovary	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1389
p.T783M	NCI-H23	lung	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.2778
p.T881M	SNU-423	liver	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7423
p.T881M	SNU-C2B	large intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7423
p.S742A	GCIY	stomach	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.3056
p.S742A	GCIY	stomach	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1944
p.G439A	YT	haematopoietic and lymphoid tissue	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation blocking phosphorylation signal	0.5278
p.K740N	Farage	haematopoietic and lymphoid tissue	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.25
p.K740N	Farage	haematopoietic and lymphoid tissue	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1389
p.M880I	LU-165	lung	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7618
p.Q871H	SN12C	kidney	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1111
p.T779M	SW1116	large intestine	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.7423
p.F431V	FTC-133	thyroid	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.3056
p.A891V	HT-115	large intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1111
p.T772M	SNU-423	liver	COSMIC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1111
p.T772M	SNU-423	liver	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1944
p.T772M	SNU-C2B	large intestine	COSMIC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation rewiring degron network	0.1111
p.T772M	SNU-C2B	large intestine	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1944
p.N783S	BE-13	haematopoietic and lymphoid tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.2778
p.M431I	UACC-62	skin	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.3056
p.G419A	YT	haematopoietic and lymphoid tissue	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.25
p.I880V	LAN-6	autonomic ganglia	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7076
p.G418S	SNU-1040	large intestine	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation rewiring degron network	0.2222
p.N884S	BE-13	haematopoietic and lymphoid tissue	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.3056
p.I875V	LAN-6	autonomic ganglia	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2222
p.R751C	FTC-133	thyroid	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation altering degron motif	0.8301
p.I874V	LAN-6	autonomic ganglia	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.Q762H	SN12C	kidney	COSMIC	PPETPVLT	DEG_SCF_FBW7_1	757:764	Mutation altering degron motif	0.7582
p.A886V	HT-115	large intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.25
p.A742T	NCI-H441	lung	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.3056
p.A742T	NCI-H441	lung	COSMIC	PPSTT	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1944
p.S427N	HCT-15	large intestine	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	422:430	Mutation altering degron motif	0.7069
p.L745F	SW403	large intestine	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6981
p.T736M	NCI-H23	lung	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.1389
p.Q744H	SN12C	kidney	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZMYND8

UniProt ID: Q9ULU4

Entrez ID: 23613

Protein name: Protein kinase C-binding protein 1 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Rack7) (Zinc finger MYND domain-containing protein 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZMYND8 in