DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PPETPVLT
Uniprot ID:
Q9ULU4
Source protein:
Protein kinase C-binding protein 1
Source gene:
ZMYND8
Class:
DEG_SCF_FBW7_1
Location:
757:764
E3 ligase:
FBXW7
DEGRON score:
0.9982
ASA_SCORE:
103.2375
COIL:
0.9398
CONS_SCORE:
0.4834
DSS_SCORE:
0.7199
HELIX:
0.0209
FCONS_SCORE:
1.2539
RIG_SCORE:
0.6584
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T770S
TCGA-56-7222
LUSC
TCGA
PPETPVLT
DEG_SCF_FBW7_1
0.1667
p.T770M
TCGA-AA-A02R
COAD
TCGA
PPETPVLT
DEG_SCF_FBW7_1
0.1667
p.P767S
TCGA-EE-A3J3
SKCM
TCGA
PPETPVLT
DEG_SCF_FBW7_1
0.25
p.P767S
TCGA-GF-A6C9
SKCM
TCGA
PPETPVLT
DEG_SCF_FBW7_1
0.25
p.P758L
DO44032
BLCA
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.6471
p.P758L
DO41097
UCEC
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.6471
p.S756C
DO218173
BRCA
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.75
p.V752A
DO227999
COCA
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.1944
p.V752A
DO229013
COCA
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.1944
p.V752A
DO229016
COCA
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.1944
p.V752A
DO233628
GACA
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.1944
p.V752A
DO229346
LAML
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.1944
p.V752A
DO229353
LAML
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.1944
p.V752A
DO228941
LICA
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.1944
p.V752A
DO228947
LICA
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.1944
p.V752A
DO231102
LUSC
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.1944
p.L763F
DO222868
MELA
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.587
p.E759D
DO50291
SKCM
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.5647
p.P757S
DO38129
SKCM
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.6752
p.P757L
DO38129
SKCM
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.6471
p.P761Q
DO229242
THCA
ICGC
PPETPVLT
DEG_SCF_FBW7_1
0.7035
p.T754M
SNU-423
liver
COSMIC
PPETPVLT
DEG_SCF_FBW7_1
0.6944
p.T754M
SNU-C2B
large_intestine
COSMIC
PPETPVLT
DEG_SCF_FBW7_1
0.6944
p.A770T
OC-314
ovary
COSMIC
PPETPVLT
DEG_SCF_FBW7_1
0.1667
p.T772M
SNU-423
liver
COSMIC
PPETPVLT
DEG_SCF_FBW7_1
0.1111
p.T772M
SNU-C2B
large_intestine
COSMIC
PPETPVLT
DEG_SCF_FBW7_1
0.1111
p.Q762H
SN12C
kidney
COSMIC
PPETPVLT
DEG_SCF_FBW7_1
0.7582
Drug responses associated with ZMYND8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPETPVLT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9ULU4
Protein kinase C-binding protein 1
DEG_SCF_FBW7_1
757:764
PPETPVLT
FBXW7
0.9982
More...