DegronMD

Uniprot ID: Q9ULU4

Source protein: Protein kinase C-binding protein 1

Source gene: ZMYND8

Class: DEG_SCF_FBW7_1

Location: 757:764

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 103.2375

COIL: 0.9398

CONS_SCORE: 0.4834

DSS_SCORE: 0.7199

HELIX: 0.0209

FCONS_SCORE: 1.2539

RIG_SCORE: 0.6584

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q762H	SN12C	kidney	COSMIC	PPETPVLT	DEG_SCF_FBW7_1	0.7582
p.S756C	DO218173	BRCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.75
p.P761Q	DO229242	THCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.7035
p.T754M	SNU-423	liver	COSMIC	PPETPVLT	DEG_SCF_FBW7_1	0.6944
p.T754M	SNU-C2B	large_intestine	COSMIC	PPETPVLT	DEG_SCF_FBW7_1	0.6944
p.P757S	DO38129	SKCM	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.6752
p.P758L	DO44032	BLCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.6471
p.P758L	DO41097	UCEC	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.6471
p.P757L	DO38129	SKCM	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.6471
p.L763F	DO222868	MELA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.587
p.E759D	DO50291	SKCM	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.5647
p.P767S	TCGA-EE-A3J3	SKCM	TCGA	PPETPVLT	DEG_SCF_FBW7_1	0.25
p.P767S	TCGA-GF-A6C9	SKCM	TCGA	PPETPVLT	DEG_SCF_FBW7_1	0.25
p.V752A	DO227999	COCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.1944
p.V752A	DO229013	COCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.1944
p.V752A	DO229016	COCA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.1944
p.V752A	DO233628	GACA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.1944
p.V752A	DO229346	LAML	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.1944
p.V752A	DO229353	LAML	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.1944
p.V752A	DO228941	LICA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.1944
p.V752A	DO228947	LICA	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.1944
p.V752A	DO231102	LUSC	ICGC	PPETPVLT	DEG_SCF_FBW7_1	0.1944
p.T770S	TCGA-56-7222	LUSC	TCGA	PPETPVLT	DEG_SCF_FBW7_1	0.1667
p.T770M	TCGA-AA-A02R	COAD	TCGA	PPETPVLT	DEG_SCF_FBW7_1	0.1667
p.A770T	OC-314	ovary	COSMIC	PPETPVLT	DEG_SCF_FBW7_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULU4	Protein kinase C-binding protein 1	DEG_SCF_FBW7_1	757:764	PPETPVLT	FBXW7	0.9982	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons