DegronMD

Uniprot ID: Q9ULU4

Source protein: Protein kinase C-binding protein 1

Source gene: ZMYND8

Class: DEG_SPOP_SBC_1

Location: 777:781

E3 ligase: SPOP

DEGRON score: 0.7077

ASA_SCORE: 90.3

COIL: 0.9332

CONS_SCORE: 0.385

DSS_SCORE: 0.5218

HELIX: 0.0336

FCONS_SCORE: 1.0007

RIG_SCORE: 0.6434

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T770S	TCGA-56-7222	LUSC	TCGA	ATTST	DEG_SPOP_SBC_1	0.1389
p.T770M	TCGA-AA-A02R	COAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.1389
p.P778L	TCGA-B5-A0KB	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	0.7582
p.P778L	TCGA-FD-A5BT	BLCA	TCGA	ATTST	DEG_SPOP_SBC_1	0.7582
p.E779D	TCGA-D9-A6EC	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	0.6758
p.P777L	TCGA-DA-A1HW	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	0.7582
p.P777S	TCGA-DA-A1HW	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	0.6752
p.P767S	TCGA-EE-A3J3	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	0.0556
p.P767S	TCGA-GF-A6C9	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	0.0556
p.V787I	DO223732	CESC	ICGC	ATTST	DEG_SPOP_SBC_1	0.1667
p.T778N	DO233869	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	0.5944
p.T784M	DO14329	HNSC	ICGC	ATTST	DEG_SPOP_SBC_1	0.25
p.T784M	ACH-000489	Colon/Colorectal Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.25
p.T784M	SW1116	large_intestine	COSMIC	ATTST	DEG_SPOP_SBC_1	0.25
p.A791P	DO219881	SKCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.0556
p.A791P	DO218884	SKCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.0556
p.S780N	DO219784	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	0.7069
p.A779T	ACH-000270	Pancreatic Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.7139
p.A779T	ACH-001098	Pancreatic Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.7139
p.A779T	HPAC	pancreas	COSMIC	ATTST	DEG_SPOP_SBC_1	0.7139
p.N778S	ACH-000519	Leukemia	CCLE	ATTST	DEG_SPOP_SBC_1	0.7069
p.N778S	ACH-002216	Leukemia	CCLE	ATTST	DEG_SPOP_SBC_1	0.7069
p.N778S	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	0.7069
p.S776L	ACH-000529	Non-Cancerous	CCLE	ATTST	DEG_SPOP_SBC_1	0.3056
p.T788M	ACH-000900	Lung Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.1389
p.T788M	NCI-H23	lung	COSMIC	ATTST	DEG_SPOP_SBC_1	0.1389
p.A784T	ACH-000952	Prostate Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.25
p.A784T	HPAC	pancreas	COSMIC	ATTST	DEG_SPOP_SBC_1	0.25
p.A775T	ACH-000962	Ovarian Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.2778
p.A775T	OC-314	ovary	COSMIC	ATTST	DEG_SPOP_SBC_1	0.2778
p.A789T	NCI-H441	lung	COSMIC	ATTST	DEG_SPOP_SBC_1	0.1111
p.A770T	OC-314	ovary	COSMIC	ATTST	DEG_SPOP_SBC_1	0.1389
p.T783M	NCI-H23	lung	COSMIC	ATTST	DEG_SPOP_SBC_1	0.2778
p.T779M	SW1116	large_intestine	COSMIC	ATTST	DEG_SPOP_SBC_1	0.7423
p.T772M	SNU-423	liver	COSMIC	ATTST	DEG_SPOP_SBC_1	0.1944
p.T772M	SNU-C2B	large_intestine	COSMIC	ATTST	DEG_SPOP_SBC_1	0.1944
p.N783S	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	441:445	ATTST	SPOP	0.9431	More...
P51608	Methyl-CpG-binding protein 2	DEG_SPOP_SBC_1	239:243	ATTST	SPOP	0.9886	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2872:2876	ATTST	SPOP	0.9946	More...
Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1	DEG_SPOP_SBC_1	213:217	ATTST	SPOP	0.9958	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7054:7058	ATTST	SPOP	0.993	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7208:7212	ATTST	SPOP	0.9812	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7378:7382	ATTST	SPOP	0.9975	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7857:7861	ATTST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7997:8001	ATTST	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8677:8681	ATTST	SPOP	0.6935	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	163:167	ATTST	SPOP	0.9828	More...
Q9BX70	BTB/POZ domain-containing protein 2	DEG_SPOP_SBC_1	155:159	ATTST	SPOP	0.8059	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	166:170	ATTST	SPOP	0.9977	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	330:334	ATTST	SPOP	0.8881	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	777:781	ATTST	SPOP	0.7077	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	685:689	ATTST	SPOP	0.881	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	567:571	ATTST	SPOP	0.7558	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	96:100	ATTST	SPOP	0.9787	More...
Q8NC74	RBBP8 N-terminal-like protein	DEG_SPOP_SBC_1	591:595	ATTST	SPOP	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTST

Degron related mutations and impact score

Drug responses associated with ZMYND8 mutations

All proteins holding degron of ATTST