DegronMD

Uniprot ID: P35869

Source protein: Aryl hydrocarbon receptor

Source gene: AHR

Class: DEG_SPOP_SBC_1

Location: 441:445

E3 ligase: SPOP

DEGRON score: 0.9431

ASA_SCORE: 83.14

COIL: 0.906

CONS_SCORE: 0.2871

DSS_SCORE: 0.607

HELIX: 0.0702

FCONS_SCORE: 0.8424

RIG_SCORE: 0.6732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S440Y	TCGA-06-5416	GBM	TCGA	ATTST	DEG_SPOP_SBC_1	0.75
p.S440Y	DO10880	GBM	ICGC	ATTST	DEG_SPOP_SBC_1	0.75
p.L451F	TCGA-33-A4WN	LUSC	TCGA	ATTST	DEG_SPOP_SBC_1	0.1667
p.L451F	DO219121	LUSC	ICGC	ATTST	DEG_SPOP_SBC_1	0.1667
p.G437V	TCGA-C4-A0F0	BLCA	TCGA	ATTST	DEG_SPOP_SBC_1	0.2222
p.G437V	DO520	BLCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.2222
p.T445A	TCGA-F5-6814	READ	TCGA	ATTST	DEG_SPOP_SBC_1	0.7139
p.T445A	DO36556	READ	ICGC	ATTST	DEG_SPOP_SBC_1	0.7139
p.G437A	TCGA-XF-AAN2	BLCA	TCGA	ATTST	DEG_SPOP_SBC_1	0.2222
p.G437A	DO219052	BLCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.2222
p.K448N	DO232761	PBCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.3611
p.S455F	SIDM00545	Melanoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.0556
p.S455F	ACH-000987	Skin Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.0556
p.S455F	Mewo	skin	COSMIC	ATTST	DEG_SPOP_SBC_1	0.0556
p.K432T	SIDM01588	Endometrial Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.1944
p.K432T	ACH-000993	Endometrial/Uterine Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.1944
p.S440F	Mewo	skin	COSMIC	ATTST	DEG_SPOP_SBC_1	0.75
p.L441F	DBTRG-05MG	central_nervous_system	COSMIC	ATTST	DEG_SPOP_SBC_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	441:445	ATTST	SPOP	0.9431	More...
P51608	Methyl-CpG-binding protein 2	DEG_SPOP_SBC_1	239:243	ATTST	SPOP	0.9886	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2872:2876	ATTST	SPOP	0.9946	More...
Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1	DEG_SPOP_SBC_1	213:217	ATTST	SPOP	0.9958	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7054:7058	ATTST	SPOP	0.993	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7208:7212	ATTST	SPOP	0.9812	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7378:7382	ATTST	SPOP	0.9975	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7857:7861	ATTST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7997:8001	ATTST	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8677:8681	ATTST	SPOP	0.6935	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	163:167	ATTST	SPOP	0.9828	More...
Q9BX70	BTB/POZ domain-containing protein 2	DEG_SPOP_SBC_1	155:159	ATTST	SPOP	0.8059	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	166:170	ATTST	SPOP	0.9977	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	330:334	ATTST	SPOP	0.8881	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	777:781	ATTST	SPOP	0.7077	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	685:689	ATTST	SPOP	0.881	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	567:571	ATTST	SPOP	0.7558	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	96:100	ATTST	SPOP	0.9787	More...
Q8NC74	RBBP8 N-terminal-like protein	DEG_SPOP_SBC_1	591:595	ATTST	SPOP	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons