DegronMD - P51608(MECP2)

GO - Biological processes (BP): adult locomotory behavior [GO:0008344]; behavioral fear response [GO:0001662]; cardiolipin metabolic process [GO:0032048]; cellular biogenic amine metabolic process [GO:0006576]; cerebellum development [GO:0021549]; dendrite development [GO:0016358]; excitatory postsynaptic potential [GO:0060079]; glucocorticoid metabolic process [GO:0008211]; glutamine metabolic process [GO:0006541]; heterochromatin assembly [GO:0031507]; histone acetylation [GO:0016573]; histone methylation [GO:0016571]; inositol metabolic process [GO:0006020]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; mitotic spindle organization [GO:0007052]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000820]; nervous system process involved in regulation of systemic arterial blood pressure [GO:0001976]; neuron maturation [GO:0042551]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA methylation [GO:1905643]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of histone H3-K9 trimethylation [GO:1900114]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; proprioception [GO:0019230]; protein localization [GO:0008104]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to hypoxia [GO:0001666]; response to other organism [GO:0051707]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; startle response [GO:0001964]; synapse assembly [GO:0007416]; ventricular system development [GO:0021591]; visual learning [GO:0008542] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A62G	TCGA-05-4382	LUAD	TCGA	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1667
p.P60Q	TCGA-06-5416	GBM	TCGA	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1111
p.S82Y	TCGA-17-Z015	LUAD	TCGA	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation substituting flanking lysine	0.3056
p.S82Y	TCGA-17-Z015	LUAD	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation substituting flanking lysine	0.1944
p.G81C	TCGA-17-Z018	LUAD	TCGA	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.2222
p.G81C	TCGA-17-Z018	LUAD	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.0556
p.R101H	TCGA-32-2616	GBM	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.2222
p.R101H	SIDM01424	B-Lymphoblastic Leukemia	GDSC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.2222
p.E88K	TCGA-55-A4DF	LUAD	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.25
p.R96W	TCGA-B5-A0K7	UCEC	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation altering degron motif	0.8634
p.R97C	TCGA-B5-A11N	UCEC	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation altering degron motif	0.8301
p.R97C	TCGA-B6-A0IJ	BRCA	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation altering degron motif	0.8301
p.R97C	SIDM00217	Colorectal Carcinoma	GDSC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation altering degron motif	0.8301
p.R97C	SNU-1040	large intestine	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation altering degron motif	0.8301
p.A85V	TCGA-B8-5551	KIRC	TCGA	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1111
p.A85V	TCGA-B8-5551	KIRC	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.1667
p.M236I	TCGA-EY-A1GU	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.E247K	TCGA-FD-A6TC	BLCA	TCGA	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2222
p.P229S	TCGA-FS-A1YY	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	239:243	Mutation blocking phosphorylation signal	0.5
p.S90A	TCGA-VQ-A8PX	STAD	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.3056
p.E235K	DO49755	BLCA	ICGC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2222
p.E102K	DO218976	BLCA	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.1944
p.R85C	DO2813	BRCA	ICGC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1111
p.R85C	DO2813	BRCA	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.1667
p.R85C	DO41458	UCEC	ICGC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1111
p.R85C	DO41458	UCEC	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.1667
p.R85C	ACH-000999	Colon/Colorectal Cancer	CCLE	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1111
p.R85C	ACH-000999	Colon/Colorectal Cancer	CCLE	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.1667
p.R85C	SNU-1040	large intestine	COSMIC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1111
p.R85C	SNU-1040	large intestine	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.1667
p.R106Q	DO223732	CESC	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.0833
p.R85H	DO233156	GACA	ICGC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1111
p.R85H	DO233156	GACA	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.1667
p.R89H	DO13462	GBM	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.2778
p.R89H	ACH-000782	Leukemia	CCLE	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.2778
p.R89H	ACH-001735	Leukemia	CCLE	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.2778
p.A73V	DO19068	KIRC	ICGC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation altering degron motif	0.5825
p.P75T	DO229041	LICA	ICGC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation altering degron motif	0.7031
p.E76K	DO45318	LUAD	ICGC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation altering degron motif	0.7022
p.G236R	DO229470	SKCA	ICGC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.Q244K	DO37413	SKCM	ICGC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.S78A	DO51778	STAD	ICGC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation blocking phosphorylation signal	0.75
p.R106W	DO47867	STAD	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.0833
p.K107N	DO229253	THCA	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation substituting flanking lysine	0.1667
p.G252D	DO41746	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0833
p.R84W	DO41295	UCEC	ICGC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1389
p.R84W	DO41295	UCEC	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.1389
p.G244A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM01040	Ovarian Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM00293	Small Cell Lung Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM00533	Pancreatic Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM00235	Kidney Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM00489	Oral Cavity Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM00247	Gastric Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM00613	Glioblastoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM01612	Endometrial Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM01690	Plasma Cell Myeloma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G244A	SIDM01685	B-Lymphoblastic Leukemia	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.A83T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1667
p.A83T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.1111
p.A83T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.1667
p.A83T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.1111
p.S241L	SIDM00974	Melanoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7667
p.S241L	WM35	skin	COSMIC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7667
p.G243E	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7199
p.V58M	SIDM00451	T-Lymphoblastic Leukemia	GDSC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.0556
p.V58M	PF-382	haematopoietic and lymphoid tissue	COSMIC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.0556
p.K94T	SIDM00901	Endometrial Carcinoma	GDSC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation altering degron motif	0.7306
p.K94T	AN3-CA	endometrium	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation altering degron motif	0.7306
p.K235N	SIDM01617	Endometrial Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2222
p.A71T	ACH-000995	Leukemia	CCLE	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation altering degron motif	0.6028
p.A71T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation altering degron motif	0.6028
p.P230S	ACH-001066	Bone Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0833
p.G231E	ACH-002337	Lung Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1111
p.K82T	AN3-CA	endometrium	COSMIC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation substituting flanking lysine	0.3056
p.K82T	AN3-CA	endometrium	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation substituting flanking lysine	0.1944
p.A67T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.3056
p.S229L	WM35	skin	COSMIC	ATTST	DEG_SPOP_SBC_1	239:243	Mutation blocking phosphorylation signal	0.5
p.R81C	SNU-1040	large intestine	COSMIC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation rewiring degron network	0.2222
p.R81C	SNU-1040	large intestine	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	91:97	Mutation rewiring degron network	0.0556
p.K78T	AN3-CA	endometrium	COSMIC	SGSAPAVPEA	DEG_COP1_1	68:77	Mutation blocking phosphorylation signal	0.75

Kaplan plot for MECP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MECP2

UniProt ID: P51608

Entrez ID: 4204

Protein name: Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MECP2 in