DegronMD

Uniprot ID: P51608

Source protein: Methyl-CpG-binding protein 2

Source gene: MECP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 91:97

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9274

ASA_SCORE: 84.0143

COIL: 0.8769

CONS_SCORE: 0.5491

DSS_SCORE: 0.6081

HELIX: 0.0507

FCONS_SCORE: 0.8987

RIG_SCORE: 0.6655

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S82Y	TCGA-17-Z015	LUAD	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G81C	TCGA-17-Z018	LUAD	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R101H	TCGA-32-2616	GBM	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R101H	SIDM01424	B-Lymphoblastic Leukemia	GDSC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E88K	TCGA-55-A4DF	LUAD	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.25
p.R96W	TCGA-B5-A0K7	UCEC	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R97C	TCGA-B5-A11N	UCEC	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R97C	TCGA-B6-A0IJ	BRCA	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R97C	SIDM00217	Colorectal Carcinoma	GDSC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R97C	SNU-1040	large_intestine	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.8301
p.A85V	TCGA-B8-5551	KIRC	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S90A	TCGA-VQ-A8PX	STAD	TCGA	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E102K	DO218976	BLCA	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R85C	DO2813	BRCA	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R85C	DO41458	UCEC	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R85C	ACH-000999	Colon/Colorectal Cancer	CCLE	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R85C	SNU-1040	large_intestine	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R106Q	DO223732	CESC	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R85H	DO233156	GACA	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R89H	DO13462	GBM	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R89H	ACH-000782	Leukemia	CCLE	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R89H	ACH-001735	Leukemia	CCLE	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R106W	DO47867	STAD	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.K107N	DO229253	THCA	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R84W	DO41295	UCEC	ICGC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A83T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A83T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.K94T	SIDM00901	Endometrial Carcinoma	GDSC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.7306
p.K94T	AN3-CA	endometrium	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.7306
p.K82T	AN3-CA	endometrium	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R81C	SNU-1040	large_intestine	COSMIC	RGPMYDD	LIG_APCC_ABBAyCdc20_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RGPMYDD

Degron related mutations and impact score

Drug responses associated with MECP2 mutations

All proteins holding degron of RGPMYDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51608	Methyl-CpG-binding protein 2	LIG_APCC_ABBAyCdc20_2	91:97	RGPMYDD	APC,CDC20,FZR1	0.9274	More...