DegronMD

Uniprot ID: P51608

Source protein: Methyl-CpG-binding protein 2

Source gene: MECP2

Class: DEG_COP1_1

Location: 68:77

E3 ligase: COP1

DEGRON score: 0.9984

ASA_SCORE: 77.94

COIL: 0.9059

CONS_SCORE: 0.4568

DSS_SCORE: 0.7456

HELIX: 0.0383

FCONS_SCORE: 1.192

RIG_SCORE: 0.5599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A62G	TCGA-05-4382	LUAD	TCGA	SGSAPAVPEA	DEG_COP1_1	0.1667
p.P60Q	TCGA-06-5416	GBM	TCGA	SGSAPAVPEA	DEG_COP1_1	0.1111
p.S82Y	TCGA-17-Z015	LUAD	TCGA	SGSAPAVPEA	DEG_COP1_1	0.3056
p.G81C	TCGA-17-Z018	LUAD	TCGA	SGSAPAVPEA	DEG_COP1_1	0.2222
p.A85V	TCGA-B8-5551	KIRC	TCGA	SGSAPAVPEA	DEG_COP1_1	0.1111
p.R85C	DO2813	BRCA	ICGC	SGSAPAVPEA	DEG_COP1_1	0.1111
p.R85C	DO41458	UCEC	ICGC	SGSAPAVPEA	DEG_COP1_1	0.1111
p.R85C	ACH-000999	Colon/Colorectal Cancer	CCLE	SGSAPAVPEA	DEG_COP1_1	0.1111
p.R85C	SNU-1040	large_intestine	COSMIC	SGSAPAVPEA	DEG_COP1_1	0.1111
p.R85H	DO233156	GACA	ICGC	SGSAPAVPEA	DEG_COP1_1	0.1111
p.A73V	DO19068	KIRC	ICGC	SGSAPAVPEA	DEG_COP1_1	0.5825
p.P75T	DO229041	LICA	ICGC	SGSAPAVPEA	DEG_COP1_1	0.7031
p.E76K	DO45318	LUAD	ICGC	SGSAPAVPEA	DEG_COP1_1	0.7022
p.S78A	DO51778	STAD	ICGC	SGSAPAVPEA	DEG_COP1_1	0.75
p.R84W	DO41295	UCEC	ICGC	SGSAPAVPEA	DEG_COP1_1	0.1389
p.A83T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	SGSAPAVPEA	DEG_COP1_1	0.1667
p.A83T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	SGSAPAVPEA	DEG_COP1_1	0.1667
p.V58M	SIDM00451	T-Lymphoblastic Leukemia	GDSC	SGSAPAVPEA	DEG_COP1_1	0.0556
p.V58M	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	SGSAPAVPEA	DEG_COP1_1	0.0556
p.A71T	ACH-000995	Leukemia	CCLE	SGSAPAVPEA	DEG_COP1_1	0.6028
p.A71T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	SGSAPAVPEA	DEG_COP1_1	0.6028
p.K82T	AN3-CA	endometrium	COSMIC	SGSAPAVPEA	DEG_COP1_1	0.3056
p.A67T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	SGSAPAVPEA	DEG_COP1_1	0.3056
p.R81C	SNU-1040	large_intestine	COSMIC	SGSAPAVPEA	DEG_COP1_1	0.2222
p.K78T	AN3-CA	endometrium	COSMIC	SGSAPAVPEA	DEG_COP1_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51608	Methyl-CpG-binding protein 2	DEG_COP1_1	68:77	SGSAPAVPEA	COP1	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SGSAPAVPEA

Degron related mutations and impact score

Drug responses associated with MECP2 mutations

All proteins holding degron of SGSAPAVPEA