DegronMD

Uniprot ID: P51608

Source protein: Methyl-CpG-binding protein 2

Source gene: MECP2

Class: DEG_SPOP_SBC_1

Location: 239:243

E3 ligase: SPOP

DEGRON score: 0.9886

ASA_SCORE: 82.88

COIL: 0.8982

CONS_SCORE: 0.5571

DSS_SCORE: 0.6386

HELIX: 0.0428

FCONS_SCORE: 1.0617

RIG_SCORE: 0.6886

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M236I	TCGA-EY-A1GU	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	0.25
p.E247K	TCGA-FD-A6TC	BLCA	TCGA	ATTST	DEG_SPOP_SBC_1	0.2222
p.P229S	TCGA-FS-A1YY	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	0.5
p.E235K	DO49755	BLCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.2222
p.G236R	DO229470	SKCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.25
p.Q244K	DO37413	SKCM	ICGC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G252D	DO41746	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	0.0833
p.G244A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM01040	Ovarian Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM00293	Small Cell Lung Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM00533	Pancreatic Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM00235	Kidney Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM00489	Oral Cavity Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM00247	Gastric Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM00613	Glioblastoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM01612	Endometrial Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM01690	Plasma Cell Myeloma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.G244A	SIDM01685	B-Lymphoblastic Leukemia	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.S241L	SIDM00974	Melanoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.7667
p.S241L	WM35	skin	COSMIC	ATTST	DEG_SPOP_SBC_1	0.7667
p.G243E	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.7199
p.K235N	SIDM01617	Endometrial Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.2222
p.P230S	ACH-001066	Bone Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.0833
p.G231E	ACH-002337	Lung Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.1111
p.S229L	WM35	skin	COSMIC	ATTST	DEG_SPOP_SBC_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	441:445	ATTST	SPOP	0.9431	More...
P51608	Methyl-CpG-binding protein 2	DEG_SPOP_SBC_1	239:243	ATTST	SPOP	0.9886	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2872:2876	ATTST	SPOP	0.9946	More...
Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1	DEG_SPOP_SBC_1	213:217	ATTST	SPOP	0.9958	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7054:7058	ATTST	SPOP	0.993	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7208:7212	ATTST	SPOP	0.9812	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7378:7382	ATTST	SPOP	0.9975	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7857:7861	ATTST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7997:8001	ATTST	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8677:8681	ATTST	SPOP	0.6935	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	163:167	ATTST	SPOP	0.9828	More...
Q9BX70	BTB/POZ domain-containing protein 2	DEG_SPOP_SBC_1	155:159	ATTST	SPOP	0.8059	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	166:170	ATTST	SPOP	0.9977	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	330:334	ATTST	SPOP	0.8881	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	777:781	ATTST	SPOP	0.7077	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	685:689	ATTST	SPOP	0.881	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	567:571	ATTST	SPOP	0.7558	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	96:100	ATTST	SPOP	0.9787	More...
Q8NC74	RBBP8 N-terminal-like protein	DEG_SPOP_SBC_1	591:595	ATTST	SPOP	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTST

Degron related mutations and impact score

Drug responses associated with MECP2 mutations

All proteins holding degron of ATTST