DegronMD

Uniprot ID: Q8NC74

Source protein: RBBP8 N-terminal-like protein

Source gene: RBBP8NL

Class: DEG_SPOP_SBC_1

Location: 591:595

E3 ligase: SPOP

DEGRON score: 0.9494

ASA_SCORE: 83.44

COIL: 0.9544

CONS_SCORE: 0.2786

DSS_SCORE: 0.6677

HELIX: 0.0244

FCONS_SCORE: 0.9664

RIG_SCORE: 0.6113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T593R	TCGA-AF-2689	READ	TCGA	ATTST	DEG_SPOP_SBC_1	0.7876
p.T593R	DO36822	READ	ICGC	ATTST	DEG_SPOP_SBC_1	0.7876
p.G599E	TCGA-CC-A9FW	LIHC	TCGA	ATTST	DEG_SPOP_SBC_1	0.2222
p.G599E	DO219557	LIHC	ICGC	ATTST	DEG_SPOP_SBC_1	0.2222
p.E582K	DO223048	ESCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.0833
p.A589E	DO229019	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	0.2778
p.S586R	DO229036	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	0.1944
p.T596N	DO229041	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	0.3056
p.S594R	DO229060	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	0.7427
p.T593M	DO230918	LUSC	ICGC	ATTST	DEG_SPOP_SBC_1	0.7423
p.T593M	DO224546	LUSC	ICGC	ATTST	DEG_SPOP_SBC_1	0.7423
p.G597R	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.2778
p.G597R	ACH-000677	Lung Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.2778
p.G597R	SW1573	lung	COSMIC	ATTST	DEG_SPOP_SBC_1	0.2778
p.T605I	SIDM00516	Melanoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.0556
p.T605I	ACH-002166	Skin Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.0556
p.T605I	MZ7-mel	skin	COSMIC	ATTST	DEG_SPOP_SBC_1	0.0556
p.P600H	SIDM01726	Ewing's Sarcoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.1944
p.P600H	ACH-000119	Non-Cancerous	CCLE	ATTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	441:445	ATTST	SPOP	0.9431	More...
P51608	Methyl-CpG-binding protein 2	DEG_SPOP_SBC_1	239:243	ATTST	SPOP	0.9886	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2872:2876	ATTST	SPOP	0.9946	More...
Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1	DEG_SPOP_SBC_1	213:217	ATTST	SPOP	0.9958	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7054:7058	ATTST	SPOP	0.993	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7208:7212	ATTST	SPOP	0.9812	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7378:7382	ATTST	SPOP	0.9975	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7857:7861	ATTST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7997:8001	ATTST	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8677:8681	ATTST	SPOP	0.6935	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	163:167	ATTST	SPOP	0.9828	More...
Q9BX70	BTB/POZ domain-containing protein 2	DEG_SPOP_SBC_1	155:159	ATTST	SPOP	0.8059	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	166:170	ATTST	SPOP	0.9977	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	330:334	ATTST	SPOP	0.8881	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	777:781	ATTST	SPOP	0.7077	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	685:689	ATTST	SPOP	0.881	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	567:571	ATTST	SPOP	0.7558	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	96:100	ATTST	SPOP	0.9787	More...
Q8NC74	RBBP8 N-terminal-like protein	DEG_SPOP_SBC_1	591:595	ATTST	SPOP	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons