DegronMD

Uniprot ID: Q9H2X6

Source protein: Homeodomain-interacting protein kinase 2

Source gene: HIPK2

Class: DEG_SPOP_SBC_1

Location: 166:170

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 78.06

COIL: 0.83

CONS_SCORE: 0.3261

DSS_SCORE: 0.5377

HELIX: 0.0242

FCONS_SCORE: 0.7927

RIG_SCORE: 0.7111

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A161S	TCGA-44-6774	LUAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.1944
p.A161S	DO25000	LUAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.1944
p.S180C	TCGA-E7-A3Y1	BLCA	TCGA	ATTST	DEG_SPOP_SBC_1	0.0556
p.S180C	DO528	BLCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.0556
p.A171T	TCGA-FP-A4BE	STAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.3056
p.A171T	DO233898	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	0.3056
p.A171T	DO48016	STAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.3056
p.S178P	DO233179	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	0.1111
p.G160R	DO233941	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	0.1667
p.G160R	SIDM00449	B-Lymphoblastic Leukemia	GDSC	ATTST	DEG_SPOP_SBC_1	0.1667
p.G160R	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	0.1667
p.S176R	DO229038	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	0.1667
p.N157D	SIDM01617	Endometrial Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.0833
p.N157D	ACH-000994	Endometrial/Uterine Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.0833

Drug responses associated with HIPK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.E136D (No)	GDSC	PI-103	186.6479
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D502N (No)	GDSC	PI-103	1.081
SIDM00951	LAML\|acute_myeloid_leukaemia	p.I227T (No)	GDSC	PI-103	1.081
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G1184V (No)	GDSC	PI-103	0.1231
SIDM00680	COREAD\|large_intestine	p.R554Q (No)	GDSC	PI-103	131.335
SIDM01045	UCEC\|endometrium	p.L59fs*56 (No)	GDSC	PI-103	3.7811
SIDM00499	PRAD\|prostate	p.G45D (No)	GDSC	PI-103	0.3537
SIDM00145	ALL\|lymphoblastic_leukemia	p.N914K (No)	GDSC	PI-103	0.1685
SIDM00108	SKCM\|melanoma	p.H322Q (No)	GDSC	PI-103	2.1752
SIDM00351	HNSC\|head_and_neck	p.R868W (No)	GDSC	PI-103	1.0036
SIDM00976	SKCM\|melanoma	p.G348R (No)	GDSC	PI-103	0.2229
SIDM00045	STAD\|stomach	p.C658F (No)	GDSC	PI-103	0.7557
SIDM01107	SKCM\|melanoma	p.T602P (No)	GDSC	PI-103	57.4273
SIDM01007	ALL\|lymphoblastic_leukemia	p.H807R (No)	GDSC	PI-103	0.2023
SIDM01007	ALL\|lymphoblastic_leukemia	p.K805R (No)	GDSC	PI-103	0.2023
SIDM01073	UNCLASSIFIED\|hairy_cell_leukaemia	p.S142N (No)	GDSC	PI-103	0.2031
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.H760R (No)	GDSC	PI-103	2.0651
SIDM00565	HNSC\|head_and_neck	p.V737M (No)	GDSC	PI-103	2.2952
SIDM00443	DLBC\|B_cell_lymphoma	p.R941C (No)	GDSC	PI-103	0.0219
SIDM00377	UNCLASSIFIED\|uterus	p.H540R (No)	GDSC	PI-103	2.6284
SIDM00498	COREAD\|large_intestine	p.I603V (No)	GDSC	PI-103	3.2887
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.A624V (No)	GDSC	PI-103	0.0783
SIDM01045	UCEC\|endometrium	p.V94E (No)	GDSC	PI-103	3.7811
SIDM00946	ALL\|T_cell_leukemia	p.V50M (No)	GDSC	PI-103	0.526
SIDM00864	CESC\|cervix	p.I875V (No)	GDSC	PI-103	23.1182
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.R433S (No)	GDSC	PI-103	131.0205
SIDM00217	COREAD\|large_intestine	p.A1178V (No)	GDSC	PI-103	1.8634
SIDM00217	COREAD\|large_intestine	p.E896K (No)	GDSC	PI-103	1.8634
SIDM01003	ALL\|lymphoblastic_leukemia	p.R497Q (No)	GDSC	PI-103	0.2158
SIDM00216	COREAD\|large_intestine	p.I146T (No)	GDSC	PI-103	20.9452
SIDM00596	UCEC\|endometrium	p.R498Q (No)	GDSC	PI-103	22.6646
SIDM00282	COREAD\|large_intestine	p.A719S (No)	GDSC	PI-103	28.6572
SIDM00660	COREAD\|large_intestine	p.A512V (No)	GDSC	PI-103	0.5852
SIDM00955	SKCM\|melanoma	p.T1022N (No)	GDSC	PI-103	14.8056
SIDM00783	COREAD\|large_intestine	p.R792W (No)	GDSC	PI-103	0.5867
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I33V (No)	GDSC	PI-103	0.0974
SIDM00789	COREAD\|large_intestine	p.V67I (No)	GDSC	PI-103	0.8427
SIDM00534	COREAD\|large_intestine	p.V1121A (No)	GDSC	PI-103	137.3337
SIDM00149	SKCM\|melanoma	p.M635I (No)	GDSC	PI-103	3.9173
SIDM00545	SKCM\|melanoma	p.R1056Q (No)	GDSC	PI-103	9.7833
SIDM00545	SKCM\|melanoma	p.H524Y (No)	GDSC	PI-103	9.7833
SIDM00114	MESO\|mesothelioma	p.L716I (No)	GDSC	PI-103	6.8017
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R133H (No)	GDSC	PI-103	0.976
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L108F (No)	GDSC	PI-103	0.2536
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.S317I (No)	GDSC	PI-103	17.6642
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.F500V (No)	GDSC	PI-103	1.0649
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y468N (No)	GDSC	PI-103	1.0649
SIDM00537	COREAD\|large_intestine	p.T125A (No)	GDSC	PI-103	32.6383
SIDM00799	GBM\|glioma	p.S1002Y (No)	GDSC	PI-103	54.1746
SIDM00496	THCA\|thyroid	p.Q747K (No)	GDSC	PI-103	0.4742
SIDM00878	BRCA\|breast	p.R833C (No)	GDSC	PI-103	0.1835

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	441:445	ATTST	SPOP	0.9431	More...
P51608	Methyl-CpG-binding protein 2	DEG_SPOP_SBC_1	239:243	ATTST	SPOP	0.9886	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2872:2876	ATTST	SPOP	0.9946	More...
Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1	DEG_SPOP_SBC_1	213:217	ATTST	SPOP	0.9958	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7054:7058	ATTST	SPOP	0.993	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7208:7212	ATTST	SPOP	0.9812	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7378:7382	ATTST	SPOP	0.9975	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7857:7861	ATTST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7997:8001	ATTST	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8677:8681	ATTST	SPOP	0.6935	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	163:167	ATTST	SPOP	0.9828	More...
Q9BX70	BTB/POZ domain-containing protein 2	DEG_SPOP_SBC_1	155:159	ATTST	SPOP	0.8059	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	166:170	ATTST	SPOP	0.9977	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	330:334	ATTST	SPOP	0.8881	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	777:781	ATTST	SPOP	0.7077	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	685:689	ATTST	SPOP	0.881	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	567:571	ATTST	SPOP	0.7558	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	96:100	ATTST	SPOP	0.9787	More...
Q8NC74	RBBP8 N-terminal-like protein	DEG_SPOP_SBC_1	591:595	ATTST	SPOP	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTST

Degron related mutations and impact score

Drug responses associated with HIPK2 mutations

All proteins holding degron of ATTST