DegronMD - Q5T3J3(LRIF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S103Y	TCGA-19-5956	GBM	TCGA	PASSS	DEG_SPOP_SBC_1	100:104	Mutation altering degron motif	0.712
p.S103Y	DO13863	GBM	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation altering degron motif	0.712
p.A91V	TCGA-2W-A8YY	CESC	TCGA	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.0833
p.A91V	DO223732	CESC	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.0833
p.D113H	TCGA-49-AAQV	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.0833
p.D113H	DO218916	LUAD	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.0833
p.K208T	TCGA-BR-8687	STAD	TCGA	ATTST	DEG_SPOP_SBC_1	213:217	Mutation substituting flanking lysine	0.3056
p.K208T	DO233872	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation substituting flanking lysine	0.3056
p.K208T	DO47801	STAD	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation substituting flanking lysine	0.3056
p.L108V	TCGA-C8-A275	BRCA	TCGA	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.2222
p.S103F	TCGA-DK-AA6S	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	100:104	Mutation altering degron motif	0.7982
p.S103F	DO219007	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation altering degron motif	0.7982
p.T214A	TCGA-EY-A1GD	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.7139
p.T214A	DO42129	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.7139
p.V215A	DO7882	COAD	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.6936
p.R205Q	DO8842	COAD	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1111
p.R205Q	DO43041	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1111
p.R205Q	DO41572	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1111
p.L223V	DO8248	COAD	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1667
p.R227C	DO233122	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.Q225K	DO233674	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1111
p.R227H	DO233737	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.R227H	DO33128	PACA	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.K101N	DO233945	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation altering degron motif	0.6918
p.K101N	DO42713	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation altering degron motif	0.6918
p.A96V	DO14204	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.2222
p.T212A	DO50799	LIRI	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.T217I	DO231382	NBL	ICGC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.7078
p.F90I	DO229213	THCA	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.0556
p.N112H	DO42129	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.1111
p.N112H	DO41542	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.1111
p.K93Q	DO43907	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.1389
p.F98V	SIDM00057	Neuroblastoma	GDSC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.2778
p.F98V	ACH-000676	Brain Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.2778
p.F98V	ACH-002389	Neuroblastoma	CCLE	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.2778
p.F98V	ACN	autonomic ganglia	COSMIC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.2778
p.M226I	SIDM01113	Other Sarcomas	GDSC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0833
p.M226I	ACH-000939	Sarcoma	CCLE	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0833
p.M226I	SK-UT-1	soft tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0833
p.K208E	SIDM00683	Prostate Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation substituting flanking lysine	0.3056
p.K208E	LNCaP-Clone-FGC	prostate	COSMIC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation substituting flanking lysine	0.3056
p.T109I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.1944
p.T109I	ACH-000980	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.1944
p.T109I	NCI-H1155	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	100:104	Mutation rewiring degron network	0.1944
p.A213V	SIDM01617	Endometrial Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.5825
p.A213V	ACH-000994	Endometrial/Uterine Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.5825
p.T215A	SIDM00959	Acute Myeloid Leukemia	GDSC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.825
p.T215A	ACH-000641	Leukemia	CCLE	ATTST	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.825
p.T215A	CMK	haematopoietic and lymphoid tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.825
p.A211V	ACH-000306	Non-Cancerous	CCLE	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.2778
p.G219V	ACH-001649	Prostate Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.2778
p.Q214H	LNCaP-Clone-FGC	prostate	COSMIC	ATTST	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRIF1

UniProt ID: Q5T3J3

Entrez ID: 55791

Protein name: Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRIF1 in