DegronMD

Uniprot ID: Q5T3J3

Source protein: Ligand-dependent nuclear receptor-interacting factor 1

Source gene: LRIF1

Class: DEG_SPOP_SBC_1

Location: 213:217

E3 ligase: SPOP

DEGRON score: 0.9958

ASA_SCORE: 82.12

COIL: 0.9266

CONS_SCORE: 0.466

DSS_SCORE: 0.3786

HELIX: 0.042

FCONS_SCORE: 0.8695

RIG_SCORE: 0.7348

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K208T	TCGA-BR-8687	STAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.3056
p.K208T	DO233872	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	0.3056
p.K208T	DO47801	STAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.3056
p.T214A	TCGA-EY-A1GD	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	0.7139
p.T214A	DO42129	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	0.7139
p.V215A	DO7882	COAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.6936
p.R205Q	DO8842	COAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.1111
p.R205Q	DO43041	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	0.1111
p.R205Q	DO41572	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	0.1111
p.L223V	DO8248	COAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.1667
p.R227C	DO233122	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	0.0556
p.Q225K	DO233674	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	0.1111
p.R227H	DO233737	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	0.0556
p.R227H	DO33128	PACA	ICGC	ATTST	DEG_SPOP_SBC_1	0.0556
p.T212A	DO50799	LIRI	ICGC	ATTST	DEG_SPOP_SBC_1	0.3056
p.T217I	DO231382	NBL	ICGC	ATTST	DEG_SPOP_SBC_1	0.7078
p.M226I	SIDM01113	Other Sarcomas	GDSC	ATTST	DEG_SPOP_SBC_1	0.0833
p.M226I	ACH-000939	Sarcoma	CCLE	ATTST	DEG_SPOP_SBC_1	0.0833
p.M226I	SK-UT-1	soft_tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	0.0833
p.K208E	SIDM00683	Prostate Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.K208E	LNCaP-Clone-FGC	prostate	COSMIC	ATTST	DEG_SPOP_SBC_1	0.3056
p.A213V	SIDM01617	Endometrial Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.5825
p.A213V	ACH-000994	Endometrial/Uterine Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.5825
p.T215A	SIDM00959	Acute Myeloid Leukemia	GDSC	ATTST	DEG_SPOP_SBC_1	0.825
p.T215A	ACH-000641	Leukemia	CCLE	ATTST	DEG_SPOP_SBC_1	0.825
p.T215A	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	0.825
p.A211V	ACH-000306	Non-Cancerous	CCLE	ATTST	DEG_SPOP_SBC_1	0.2778
p.G219V	ACH-001649	Prostate Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.2778
p.Q214H	LNCaP-Clone-FGC	prostate	COSMIC	ATTST	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	441:445	ATTST	SPOP	0.9431	More...
P51608	Methyl-CpG-binding protein 2	DEG_SPOP_SBC_1	239:243	ATTST	SPOP	0.9886	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2872:2876	ATTST	SPOP	0.9946	More...
Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1	DEG_SPOP_SBC_1	213:217	ATTST	SPOP	0.9958	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7054:7058	ATTST	SPOP	0.993	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7208:7212	ATTST	SPOP	0.9812	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7378:7382	ATTST	SPOP	0.9975	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7857:7861	ATTST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7997:8001	ATTST	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8677:8681	ATTST	SPOP	0.6935	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	163:167	ATTST	SPOP	0.9828	More...
Q9BX70	BTB/POZ domain-containing protein 2	DEG_SPOP_SBC_1	155:159	ATTST	SPOP	0.8059	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	166:170	ATTST	SPOP	0.9977	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	330:334	ATTST	SPOP	0.8881	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	777:781	ATTST	SPOP	0.7077	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	685:689	ATTST	SPOP	0.881	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	567:571	ATTST	SPOP	0.7558	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	96:100	ATTST	SPOP	0.9787	More...
Q8NC74	RBBP8 N-terminal-like protein	DEG_SPOP_SBC_1	591:595	ATTST	SPOP	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTST

Degron related mutations and impact score

Drug responses associated with LRIF1 mutations

All proteins holding degron of ATTST