DegronMD - Q8ND82(ZNF280C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G208D	TCGA-AP-A059	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.G208D	DO41361	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.S535Y	TCGA-BK-A6W3	UCEC	TCGA	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.2778
p.S535Y	TCGA-D1-A17Q	UCEC	TCGA	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.2778
p.S535Y	DO50076	UCEC	ICGC	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.2778
p.S535Y	DO41903	UCEC	ICGC	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.2778
p.N551K	TCGA-DI-A1BU	UCEC	TCGA	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1389
p.N551K	DO42023	UCEC	ICGC	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1389
p.A531T	TCGA-E6-A2P9	UCEC	TCGA	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1667
p.A531T	DO43714	UCEC	ICGC	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1667
p.T213K	DO228974	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.8417
p.A567E	DO228986	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.7701
p.A567E	DO229031	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.7701
p.P505T	DO229037	LICA	ICGC	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.1389
p.G529S	SIDM00596	Endometrial Carcinoma	GDSC	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.0833
p.G529S	SIDM00596	Endometrial Carcinoma	GDSC	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1111
p.G529S	ACH-000941	Endometrial/Uterine Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.0833
p.G529S	ACH-000941	Endometrial/Uterine Cancer	CCLE	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1111
p.G529S	ACH-000954	Endometrial/Uterine Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.0833
p.G529S	ACH-000954	Endometrial/Uterine Cancer	CCLE	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1111
p.G529S	ACH-001517	Endometrial/Uterine Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.0833
p.G529S	ACH-001517	Endometrial/Uterine Cancer	CCLE	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1111
p.G529S	HEC-1	endometrium	COSMIC	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.0833
p.G529S	HEC-1	endometrium	COSMIC	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1111
p.A526T	SIDM00121	T-Lymphoblastic Leukemia	GDSC	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.1667
p.A526T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.1667
p.T511N	ACH-000252	Colon/Colorectal Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.3056
p.T511N	ACH-000401	Skin Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.3056
p.T511N	ACH-000881	Skin Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.3056
p.T511N	ACH-000987	Skin Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.3056
p.T511N	ACH-000997	Colon/Colorectal Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	512:520	Mutation rewiring degron network	0.3056
p.R553T	ACH-001416	Bladder Cancer	CCLE	LQVTPPTS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF280C

UniProt ID: Q8ND82

Entrez ID: 55609

Protein name: Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF280C in