DegronMD

Uniprot ID: Q8ND82

Source protein: Zinc finger protein 280C

Source gene: ZNF280C

Class: DEG_SCF_FBW7_1

Location: 537:544

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 98.5625

COIL: 0.8089

CONS_SCORE: 0.2656

DSS_SCORE: 0.6385

HELIX: 0.0201

FCONS_SCORE: 1.4053

RIG_SCORE: 0.6953

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S535Y	TCGA-BK-A6W3	UCEC	TCGA	LQVTPPTS	DEG_SCF_FBW7_1	0.2778
p.S535Y	TCGA-D1-A17Q	UCEC	TCGA	LQVTPPTS	DEG_SCF_FBW7_1	0.2778
p.S535Y	DO50076	UCEC	ICGC	LQVTPPTS	DEG_SCF_FBW7_1	0.2778
p.S535Y	DO41903	UCEC	ICGC	LQVTPPTS	DEG_SCF_FBW7_1	0.2778
p.N551K	TCGA-DI-A1BU	UCEC	TCGA	LQVTPPTS	DEG_SCF_FBW7_1	0.1389
p.N551K	DO42023	UCEC	ICGC	LQVTPPTS	DEG_SCF_FBW7_1	0.1389
p.A531T	TCGA-E6-A2P9	UCEC	TCGA	LQVTPPTS	DEG_SCF_FBW7_1	0.1667
p.A531T	DO43714	UCEC	ICGC	LQVTPPTS	DEG_SCF_FBW7_1	0.1667
p.G529S	SIDM00596	Endometrial Carcinoma	GDSC	LQVTPPTS	DEG_SCF_FBW7_1	0.1111
p.G529S	ACH-000941	Endometrial/Uterine Cancer	CCLE	LQVTPPTS	DEG_SCF_FBW7_1	0.1111
p.G529S	ACH-000954	Endometrial/Uterine Cancer	CCLE	LQVTPPTS	DEG_SCF_FBW7_1	0.1111
p.G529S	ACH-001517	Endometrial/Uterine Cancer	CCLE	LQVTPPTS	DEG_SCF_FBW7_1	0.1111
p.G529S	HEC-1	endometrium	COSMIC	LQVTPPTS	DEG_SCF_FBW7_1	0.1111
p.R553T	ACH-001416	Bladder Cancer	CCLE	LQVTPPTS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8ND82	Zinc finger protein 280C	DEG_SCF_FBW7_1	537:544	LQVTPPTS	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons