DegronMD

Uniprot ID: Q8ND82

Source protein: Zinc finger protein 280C

Source gene: ZNF280C

Class: DEG_APCC_DBOX_1

Location: 512:520

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9682

ASA_SCORE: 84.0444

COIL: 0.6277

CONS_SCORE: 0.2416

DSS_SCORE: 0.4434

HELIX: 0.0786

FCONS_SCORE: 1.0389

RIG_SCORE: 0.7319

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P505T	DO229037	LICA	ICGC	IRASLGPLQ	DEG_APCC_DBOX_1	0.1389
p.G529S	SIDM00596	Endometrial Carcinoma	GDSC	IRASLGPLQ	DEG_APCC_DBOX_1	0.0833
p.G529S	ACH-000941	Endometrial/Uterine Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	0.0833
p.G529S	ACH-000954	Endometrial/Uterine Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	0.0833
p.G529S	ACH-001517	Endometrial/Uterine Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	0.0833
p.G529S	HEC-1	endometrium	COSMIC	IRASLGPLQ	DEG_APCC_DBOX_1	0.0833
p.A526T	SIDM00121	T-Lymphoblastic Leukemia	GDSC	IRASLGPLQ	DEG_APCC_DBOX_1	0.1667
p.A526T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	IRASLGPLQ	DEG_APCC_DBOX_1	0.1667
p.T511N	ACH-000252	Colon/Colorectal Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	0.3056
p.T511N	ACH-000401	Skin Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	0.3056
p.T511N	ACH-000881	Skin Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	0.3056
p.T511N	ACH-000987	Skin Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	0.3056
p.T511N	ACH-000997	Colon/Colorectal Cancer	CCLE	IRASLGPLQ	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8ND82	Zinc finger protein 280C	DEG_APCC_DBOX_1	512:520	IRASLGPLQ	APC,CDC20,FZR1	0.9682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons