DegronMD - P43366(MAGEB1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S102I	TCGA-55-7570	LUAD	TCGA	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.S102I	DO25280	LUAD	ICGC	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.W110C	TCGA-75-6211	LUAD	TCGA	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.W110C	DO25173	LUAD	ICGC	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.Q95H	TCGA-78-7146	LUAD	TCGA	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.3056
p.Q95H	DO23717	LUAD	ICGC	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.3056
p.P61S	TCGA-AP-A059	UCEC	TCGA	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.P61S	TCGA-AP-A059	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.2222
p.P61S	DO41361	UCEC	ICGC	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.P61S	DO41361	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.2222
p.T98P	TCGA-AX-A2HD	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7031
p.T98P	DO42608	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7031
p.T48I	TCGA-BH-A0BP	BRCA	TCGA	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7078
p.T48I	DO4056	BRCA	ICGC	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7078
p.I57S	TCGA-CA-6717	COAD	TCGA	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.I57S	TCGA-CA-6717	COAD	TCGA	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.1111
p.I57S	DO8264	COAD	ICGC	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.I57S	DO8264	COAD	ICGC	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.1111
p.P53T	TCGA-CN-5356	HNSC	TCGA	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.3056
p.P53T	DO15390	HNSC	ICGC	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.3056
p.E78K	TCGA-D1-A17Q	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.0833
p.E78K	DO222427	BTCA	ICGC	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.0833
p.E78K	DO229494	SKCA	ICGC	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.0833
p.E78K	DO41903	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.0833
p.W110R	TCGA-D7-A4YV	STAD	TCGA	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.W110R	DO47777	STAD	ICGC	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.V104F	TCGA-E7-A6ME	BLCA	TCGA	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2222
p.V104F	DO51874	BLCA	ICGC	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2222
p.V74L	DO225152	BRCA	ICGC	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.1944
p.P107T	DO222455	ESCA	ICGC	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.A71S	DO229038	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.2778
p.E89A	DO228440	MALY	ICGC	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.E101K	DO222363	MELA	ICGC	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.3056
p.A54V	DO229211	THCA	ICGC	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.2778
p.G46A	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6429
p.G46A	ACH-000727	Lung Cancer	CCLE	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6429
p.G46A	NCI-H2066	lung	COSMIC	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6429
p.S51R	SIDM01451	Pancreatic Carcinoma	GDSC	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6316
p.S51R	ACH-000933	Pancreatic Cancer	CCLE	LGDTPTSS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6316
p.P66L	ACH-000029	Lung Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation altering degron motif	0.6471
p.E89K	ACH-000987	Skin Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.E89K	Mewo	skin	COSMIC	ATTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.E78V	ACH-001369	Ovarian Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.0833
p.T67I	ACH-001568	Skin Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	65:69	Mutation altering degron motif	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAGEB1

UniProt ID: P43366

Entrez ID: 4112

Protein name: Melanoma-associated antigen B1 (Cancer/testis antigen 3.1) (CT3.1) (DSS-AHC critical interval MAGE superfamily 10) (DAM10) (MAGE-B1 antigen) (MAGE-XP antigen)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MAGEB1 in