DegronMD

Uniprot ID: P43366

Source protein: Melanoma-associated antigen B1

Source gene: MAGEB1

Class: DEG_SCF_FBW7_1

Location: 45:52

E3 ligase: FBXW7

DEGRON score: 0.9381

ASA_SCORE: 79.6625

COIL: 0.9043

CONS_SCORE: 0.2731

DSS_SCORE: 0.7042

HELIX: 0.0206

FCONS_SCORE: 1.0557

RIG_SCORE: 0.5957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P61S	TCGA-AP-A059	UCEC	TCGA	LGDTPTSS	DEG_SCF_FBW7_1	0.0833
p.P61S	DO41361	UCEC	ICGC	LGDTPTSS	DEG_SCF_FBW7_1	0.0833
p.T48I	TCGA-BH-A0BP	BRCA	TCGA	LGDTPTSS	DEG_SCF_FBW7_1	0.7078
p.T48I	DO4056	BRCA	ICGC	LGDTPTSS	DEG_SCF_FBW7_1	0.7078
p.I57S	TCGA-CA-6717	COAD	TCGA	LGDTPTSS	DEG_SCF_FBW7_1	0.1944
p.I57S	DO8264	COAD	ICGC	LGDTPTSS	DEG_SCF_FBW7_1	0.1944
p.P53T	TCGA-CN-5356	HNSC	TCGA	LGDTPTSS	DEG_SCF_FBW7_1	0.3056
p.P53T	DO15390	HNSC	ICGC	LGDTPTSS	DEG_SCF_FBW7_1	0.3056
p.A54V	DO229211	THCA	ICGC	LGDTPTSS	DEG_SCF_FBW7_1	0.2778
p.G46A	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	LGDTPTSS	DEG_SCF_FBW7_1	0.6429
p.G46A	ACH-000727	Lung Cancer	CCLE	LGDTPTSS	DEG_SCF_FBW7_1	0.6429
p.G46A	NCI-H2066	lung	COSMIC	LGDTPTSS	DEG_SCF_FBW7_1	0.6429
p.S51R	SIDM01451	Pancreatic Carcinoma	GDSC	LGDTPTSS	DEG_SCF_FBW7_1	0.6316
p.S51R	ACH-000933	Pancreatic Cancer	CCLE	LGDTPTSS	DEG_SCF_FBW7_1	0.6316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43366	Melanoma-associated antigen B1	DEG_SCF_FBW7_1	45:52	LGDTPTSS	FBXW7	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons