DegronMD

Uniprot ID: P43366

Source protein: Melanoma-associated antigen B1

Source gene: MAGEB1

Class: DEG_SPOP_SBC_1

Location: 96:100

E3 ligase: SPOP

DEGRON score: 0.9787

ASA_SCORE: 64.1

COIL: 0.8172

CONS_SCORE: 0.3305

DSS_SCORE: 0.5168

HELIX: 0.142

FCONS_SCORE: 1.168

RIG_SCORE: 0.6764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S102I	TCGA-55-7570	LUAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.2778
p.S102I	DO25280	LUAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.2778
p.W110C	TCGA-75-6211	LUAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.0556
p.W110C	DO25173	LUAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.0556
p.Q95H	TCGA-78-7146	LUAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.3056
p.Q95H	DO23717	LUAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.3056
p.T98P	TCGA-AX-A2HD	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	0.7031
p.T98P	DO42608	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	0.7031
p.W110R	TCGA-D7-A4YV	STAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.0556
p.W110R	DO47777	STAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.0556
p.V104F	TCGA-E7-A6ME	BLCA	TCGA	ATTST	DEG_SPOP_SBC_1	0.2222
p.V104F	DO51874	BLCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.2222
p.P107T	DO222455	ESCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.1389
p.E89A	DO228440	MALY	ICGC	ATTST	DEG_SPOP_SBC_1	0.1389
p.E101K	DO222363	MELA	ICGC	ATTST	DEG_SPOP_SBC_1	0.3056
p.E89K	ACH-000987	Skin Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.1389
p.E89K	Mewo	skin	COSMIC	ATTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	441:445	ATTST	SPOP	0.9431	More...
P51608	Methyl-CpG-binding protein 2	DEG_SPOP_SBC_1	239:243	ATTST	SPOP	0.9886	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2872:2876	ATTST	SPOP	0.9946	More...
Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1	DEG_SPOP_SBC_1	213:217	ATTST	SPOP	0.9958	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7054:7058	ATTST	SPOP	0.993	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7208:7212	ATTST	SPOP	0.9812	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7378:7382	ATTST	SPOP	0.9975	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7857:7861	ATTST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7997:8001	ATTST	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8677:8681	ATTST	SPOP	0.6935	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	163:167	ATTST	SPOP	0.9828	More...
Q9BX70	BTB/POZ domain-containing protein 2	DEG_SPOP_SBC_1	155:159	ATTST	SPOP	0.8059	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	166:170	ATTST	SPOP	0.9977	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	330:334	ATTST	SPOP	0.8881	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	777:781	ATTST	SPOP	0.7077	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	685:689	ATTST	SPOP	0.881	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	567:571	ATTST	SPOP	0.7558	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	96:100	ATTST	SPOP	0.9787	More...
Q8NC74	RBBP8 N-terminal-like protein	DEG_SPOP_SBC_1	591:595	ATTST	SPOP	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons