DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 8677:8681

E3 ligase: SPOP

DEGRON score: 0.6935

ASA_SCORE: 82.6

COIL: 0.855

CONS_SCORE: 0

DSS_SCORE: 0.549

HELIX: 0.0266

FCONS_SCORE: 0

RIG_SCORE: 0.6939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P8672H	TCGA-AD-5900	COAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.1944
p.P8672H	DO8514	COAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.1944
p.L8682P	TCGA-AD-6895	COAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.3056
p.L8682P	DO8938	COAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.3056
p.T8685R	TCGA-G9-6496	PRAD	TCGA	ATTST	DEG_SPOP_SBC_1	0.2222
p.T8685R	DO36344	PRAD	ICGC	ATTST	DEG_SPOP_SBC_1	0.2222
p.T8679I	DO228935	COCA	ICGC	ATTST	DEG_SPOP_SBC_1	0.7078
p.P8675L	DO220877	MELA	ICGC	ATTST	DEG_SPOP_SBC_1	0.2778
p.S8674Y	DO233019	PEME	ICGC	ATTST	DEG_SPOP_SBC_1	0.25
p.M8676I	SIDM00007	Other Solid Cancers	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.M8676I	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.3056
p.M8676I	ACH-000481	Lung Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.3056
p.M8676I	ACH-001550	Skin Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	0.3056
p.M8676I	MCC13	skin	COSMIC	ATTST	DEG_SPOP_SBC_1	0.3056
p.M8676I	NCI-H2170	lung	COSMIC	ATTST	DEG_SPOP_SBC_1	0.3056
p.T8678A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	ATTST	DEG_SPOP_SBC_1	0.6028
p.T8678A	ACH-000914	Lymphoma	CCLE	ATTST	DEG_SPOP_SBC_1	0.6028
p.T8678A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	0.6028
p.T8679P	LS-1034	large_intestine	COSMIC	ATTST	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	441:445	ATTST	SPOP	0.9431	More...
P51608	Methyl-CpG-binding protein 2	DEG_SPOP_SBC_1	239:243	ATTST	SPOP	0.9886	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2872:2876	ATTST	SPOP	0.9946	More...
Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1	DEG_SPOP_SBC_1	213:217	ATTST	SPOP	0.9958	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7054:7058	ATTST	SPOP	0.993	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7208:7212	ATTST	SPOP	0.9812	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7378:7382	ATTST	SPOP	0.9975	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7857:7861	ATTST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7997:8001	ATTST	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8677:8681	ATTST	SPOP	0.6935	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	163:167	ATTST	SPOP	0.9828	More...
Q9BX70	BTB/POZ domain-containing protein 2	DEG_SPOP_SBC_1	155:159	ATTST	SPOP	0.8059	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	166:170	ATTST	SPOP	0.9977	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	330:334	ATTST	SPOP	0.8881	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	777:781	ATTST	SPOP	0.7077	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	685:689	ATTST	SPOP	0.881	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	567:571	ATTST	SPOP	0.7558	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	96:100	ATTST	SPOP	0.9787	More...
Q8NC74	RBBP8 N-terminal-like protein	DEG_SPOP_SBC_1	591:595	ATTST	SPOP	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons