DegronMD - Q9Y4J8(DTNA)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E578V	TCGA-05-4382	LUAD	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation rewiring degron network	0.1111
p.E578D	TCGA-09-2044	OV	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation rewiring degron network	0.1111
p.E648Q	TCGA-37-3783	LUSC	TCGA	TQFEDLVPSP	DEG_COP1_1	654:663	Mutation rewiring degron network	0.1667
p.S308R	TCGA-44-6776	LUAD	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation blocking phosphorylation signal	0.6667
p.S308R	DO24060	LUAD	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation blocking phosphorylation signal	0.6667
p.R656L	TCGA-64-1679	LUAD	TCGA	TQFEDLVPSP	DEG_COP1_1	654:663	Mutation altering degron motif	0.8428
p.Q442E	TCGA-66-2744	LUSC	TCGA	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.L455Q	TCGA-77-7463	LUSC	TCGA	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.A440G	TCGA-77-A5GH	LUSC	TCGA	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1667
p.S308I	TCGA-AA-3715	COAD	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation blocking phosphorylation signal	0.6667
p.S308I	DO8018	COAD	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation blocking phosphorylation signal	0.6667
p.S306F	TCGA-AP-A0LM	UCEC	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1667
p.S306F	DO43306	UCEC	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1667
p.S441Y	TCGA-AX-A05Z	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.A302T	TCGA-AX-A1CE	UCEC	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.0556
p.A302T	DO42280	UCEC	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.0556
p.S441F	TCGA-BK-A6W3	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.R459W	TCGA-C5-A7CK	CESC	TCGA	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0833
p.R459W	TCGA-CM-4746	COAD	TCGA	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0833
p.M319V	TCGA-DF-A2KN	UCEC	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.6097
p.M319V	DO223282	UCEC	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.6097
p.R699C	TCGA-DI-A1BU	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.0556
p.R699C	DO42023	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.0556
p.E446Q	TCGA-DK-A2I1	BLCA	TCGA	AESSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6744
p.S577F	TCGA-E6-A1LX	UCEC	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation rewiring degron network	0.0833
p.E597A	TCGA-EI-6882	READ	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation rewiring degron network	0.2222
p.E590K	TCGA-FR-A726	SKCM	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation altering degron motif	0.7022
p.P601S	TCGA-FW-A3R5	SKCM	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation rewiring degron network	0.1111
p.E325K	TCGA-KQ-A41P	BLCA	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1944
p.E325K	DO223590	BLCA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1944
p.P321S	TCGA-XK-AAIW	PRAD	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.3056
p.P321S	DO51407	PRAD	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.3056
p.S308N	DO50568	BOCA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation blocking phosphorylation signal	0.6667
p.H317Q	DO222783	BTCA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.647
p.T685I	DO229382	BTCA	ICGC	ATTST	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.7078
p.A438S	DO222782	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.E325D	DO222884	COCA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1944
p.R313H	DO228123	EOPC	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.8244
p.E688K	DO234285	ESAD	ICGC	ATTST	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.7022
p.R305Q	DO233179	GACA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation substituting flanking lysine	0.25
p.R328Q	DO233089	GACA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1111
p.A438T	DO233908	GACA	ICGC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.P315T	DO228215	LICA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.5919
p.V681F	DO229026	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.2222
p.V681F	DO229041	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.2222
p.C691F	DO229038	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.2778
p.S448Y	DO26599	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.712
p.R319K	DO220886	MELA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.7237
p.P313H	DO229126	NKTL	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.7694
p.G311R	DO35122	PACA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.3056
p.E309A	DO36531	READ	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.25
p.S320F	DO36881	READ	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.7982
p.D310V	DO219879	SKCA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.2778
p.P313S	DO37406	SKCM	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.6752
p.P316H	DO50284	SKCM	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.7694
p.E302K	DO48665	SKCM	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.0556
p.A320T	DO37931	SKCM	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.7139
p.S449Y	DO47623	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.712
p.A323V	DO38599	STAD	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.25
p.A438V	DO41235	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.R459Q	SIDM01006	Plasma Cell Myeloma	GDSC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0833
p.R459Q	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0833
p.A448V	SIDM00282	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6936
p.A448V	CW-2	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6936
p.R593Q	SIDM00527	Colorectal Carcinoma	GDSC	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation altering degron motif	0.7329
p.G692D	ACH-000059	Leukemia	CCLE	ATTST	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.25
p.G692D	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.25
p.T587M	ACH-000563	Lung Cancer	CCLE	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation altering degron motif	0.6312
p.T587M	ACH-000943	Colon/Colorectal Cancer	CCLE	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation altering degron motif	0.6312
p.T587M	RKO	large intestine	COSMIC	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation altering degron motif	0.6312
p.T587M	EBC-1	lung	COSMIC	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation altering degron motif	0.6312
p.P590Q	ACH-000616	Gastric Cancer	CCLE	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation altering degron motif	0.7035
p.P590Q	Hs746T	stomach	COSMIC	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation altering degron motif	0.7035
p.R443G	ACH-000678	Gastric Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.R443G	MKN7	stomach	COSMIC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.R691C	ACH-000905	Bladder Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.2778
p.R691C	5637	urinary tract	COSMIC	ATTST	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.2778
p.K667N	ACH-000948	Gastric Cancer	CCLE	TQFEDLVPSP	DEG_COP1_1	654:663	Mutation substituting flanking lysine	0.3333
p.K667N	23132-87	stomach	COSMIC	TQFEDLVPSP	DEG_COP1_1	654:663	Mutation substituting flanking lysine	0.3333
p.S450L	ACH-000968	Skin Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.8778
p.S450L	COLO-792	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.8778
p.T589K	ACH-002077	Lung Cancer	CCLE	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation altering degron motif	0.7306
p.T589K	LU-165	lung	COSMIC	PTHTPQDS	DEG_SCF_FBW7_1	586:593	Mutation altering degron motif	0.7306
p.R437W	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0833
p.R313C	5637	urinary tract	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.8301
p.S447L	COLO-792	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7667
p.G314D	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.7198
p.H322D	DMS-273	lung	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.2778
p.R440G	MKN7	stomach	COSMIC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1667
p.K319N	23132-87	stomach	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.6918
p.H326D	DMS-273	lung	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation substituting flanking lysine	0.2778
p.A451V	CW-2	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	446:450	Mutation blocking phosphorylation signal	0.75
p.K315N	23132-87	stomach	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.6918

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DTNA

UniProt ID: Q9Y4J8

Entrez ID: 1837

Protein name: Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DTNA in