DegronMD

Uniprot ID: Q9Y4J8

Source protein: Dystrobrevin alpha

Source gene: DTNA

Class: DEG_SCF_FBW7_1

Location: 586:593

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 84.825

COIL: 0.9101

CONS_SCORE: 0.4522

DSS_SCORE: 0.6066

HELIX: 0.063

FCONS_SCORE: 1.1043

RIG_SCORE: 0.6354

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E578V	TCGA-05-4382	LUAD	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	0.1111
p.E578D	TCGA-09-2044	OV	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	0.1111
p.S577F	TCGA-E6-A1LX	UCEC	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	0.0833
p.E597A	TCGA-EI-6882	READ	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	0.2222
p.E590K	TCGA-FR-A726	SKCM	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	0.7022
p.P601S	TCGA-FW-A3R5	SKCM	TCGA	PTHTPQDS	DEG_SCF_FBW7_1	0.1111
p.R593Q	SIDM00527	Colorectal Carcinoma	GDSC	PTHTPQDS	DEG_SCF_FBW7_1	0.7329
p.T587M	ACH-000563	Lung Cancer	CCLE	PTHTPQDS	DEG_SCF_FBW7_1	0.6312
p.T587M	ACH-000943	Colon/Colorectal Cancer	CCLE	PTHTPQDS	DEG_SCF_FBW7_1	0.6312
p.T587M	RKO	large_intestine	COSMIC	PTHTPQDS	DEG_SCF_FBW7_1	0.6312
p.T587M	EBC-1	lung	COSMIC	PTHTPQDS	DEG_SCF_FBW7_1	0.6312
p.P590Q	ACH-000616	Gastric Cancer	CCLE	PTHTPQDS	DEG_SCF_FBW7_1	0.7035
p.P590Q	Hs746T	stomach	COSMIC	PTHTPQDS	DEG_SCF_FBW7_1	0.7035
p.T589K	ACH-002077	Lung Cancer	CCLE	PTHTPQDS	DEG_SCF_FBW7_1	0.7306
p.T589K	LU-165	lung	COSMIC	PTHTPQDS	DEG_SCF_FBW7_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4J8	Dystrobrevin alpha	DEG_SCF_FBW7_1	586:593	PTHTPQDS	FBXW7	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons