DegronMD

Uniprot ID: Q9Y4J8

Source protein: Dystrobrevin alpha

Source gene: DTNA

Class: DEG_COP1_1

Location: 654:663

E3 ligase: COP1

DEGRON score: 0.9872

ASA_SCORE: 79.97

COIL: 0.6562

CONS_SCORE: 0.3559

DSS_SCORE: 0.4704

HELIX: 0.3156

FCONS_SCORE: 1.0407

RIG_SCORE: 0.7624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E648Q	TCGA-37-3783	LUSC	TCGA	TQFEDLVPSP	DEG_COP1_1	0.1667
p.R656L	TCGA-64-1679	LUAD	TCGA	TQFEDLVPSP	DEG_COP1_1	0.8428
p.K667N	ACH-000948	Gastric Cancer	CCLE	TQFEDLVPSP	DEG_COP1_1	0.3333
p.K667N	23132-87	stomach	COSMIC	TQFEDLVPSP	DEG_COP1_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4J8	Dystrobrevin alpha	DEG_COP1_1	654:663	TQFEDLVPSP	COP1	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons