DegronMD

Uniprot ID: Q9Y4J8

Source protein: Dystrobrevin alpha

Source gene: DTNA

Class: DEG_APCC_DBOX_1

Location: 312:320

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9855

ASA_SCORE: 82.9222

COIL: 0.9098

CONS_SCORE: 0.4076

DSS_SCORE: 0.548

HELIX: 0.054

FCONS_SCORE: 0.8257

RIG_SCORE: 0.637

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S308R	TCGA-44-6776	LUAD	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	0.6667
p.S308R	DO24060	LUAD	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.6667
p.S308I	TCGA-AA-3715	COAD	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	0.6667
p.S308I	DO8018	COAD	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.6667
p.S306F	TCGA-AP-A0LM	UCEC	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	0.1667
p.S306F	DO43306	UCEC	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.1667
p.A302T	TCGA-AX-A1CE	UCEC	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	0.0556
p.A302T	DO42280	UCEC	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.0556
p.M319V	TCGA-DF-A2KN	UCEC	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	0.6097
p.M319V	DO223282	UCEC	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.6097
p.E325K	TCGA-KQ-A41P	BLCA	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	0.1944
p.E325K	DO223590	BLCA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.1944
p.P321S	TCGA-XK-AAIW	PRAD	TCGA	SREPLHPMF	DEG_APCC_DBOX_1	0.3056
p.P321S	DO51407	PRAD	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.3056
p.S308N	DO50568	BOCA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.6667
p.H317Q	DO222783	BTCA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.647
p.E325D	DO222884	COCA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.1944
p.R313H	DO228123	EOPC	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.8244
p.R305Q	DO233179	GACA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.25
p.R328Q	DO233089	GACA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.1111
p.P315T	DO228215	LICA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.5919
p.R319K	DO220886	MELA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.7237
p.P313H	DO229126	NKTL	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.7694
p.G311R	DO35122	PACA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.3056
p.E309A	DO36531	READ	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.25
p.S320F	DO36881	READ	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.7982
p.D310V	DO219879	SKCA	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.2778
p.P313S	DO37406	SKCM	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.6752
p.P316H	DO50284	SKCM	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.7694
p.E302K	DO48665	SKCM	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.0556
p.A320T	DO37931	SKCM	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.7139
p.A323V	DO38599	STAD	ICGC	SREPLHPMF	DEG_APCC_DBOX_1	0.25
p.R313C	5637	urinary_tract	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	0.8301
p.G314D	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	0.7198
p.H322D	DMS-273	lung	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	0.2778
p.K319N	23132-87	stomach	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	0.6918
p.H326D	DMS-273	lung	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	0.2778
p.K315N	23132-87	stomach	COSMIC	SREPLHPMF	DEG_APCC_DBOX_1	0.6918

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SREPLHPMF

Degron related mutations and impact score

Drug responses associated with DTNA mutations

All proteins holding degron of SREPLHPMF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4J8	Dystrobrevin alpha	DEG_APCC_DBOX_1	312:320	SREPLHPMF	APC,CDC20,FZR1	0.9855	More...