DegronMD

Uniprot ID: Q9ULU4

Source protein: Protein kinase C-binding protein 1

Source gene: ZMYND8

Class: DEG_APCC_DBOX_1

Location: 422:430

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9597

ASA_SCORE: 94.0556

COIL: 0.7863

CONS_SCORE: 0.4578

DSS_SCORE: 0.6475

HELIX: 0.1252

FCONS_SCORE: 1.07

RIG_SCORE: 0.677

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M423T	TCGA-BG-A221	UCEC	TCGA	RRISLSDMP	DEG_APCC_DBOX_1	0.7423
p.D422H	TCGA-FD-A3SR	BLCA	TCGA	RRISLSDMP	DEG_APCC_DBOX_1	0.7688
p.M434I	DO5731	BRCA	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	0.2222
p.R423Q	DO223732	CESC	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	0.7329
p.R423Q	DO32247	OV	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	0.7329
p.R422L	DO233198	GACA	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	0.7316
p.P430L	DO16335	KIRC	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	0.6471
p.P430L	DO51407	PRAD	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	0.6471
p.G421V	DO25528	LUAD	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	0.3056
p.S425F	DO220878	MELA	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	0.7982
p.S425F	DO37839	SKCM	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	0.7982
p.R431H	DO51407	PRAD	ICGC	RRISLSDMP	DEG_APCC_DBOX_1	0.3056
p.E422D	SIDM01034	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00586	Hepatocellular Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00434	Plasma Cell Myeloma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01020	Plasma Cell Myeloma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00425	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00321	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00234	Other Solid Cancers	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01151	Hepatocellular Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00617	Hepatocellular Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00367	Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00291	Melanoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01144	Gastric Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00267	Biliary Tract Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00466	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00619	Thyroid Gland Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00351	Oral Cavity Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00383	Gastric Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00599	Osteosarcoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00487	Colorectal Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00292	Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01180	Hepatocellular Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00294	Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00564	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00239	Kidney Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00580	Acute Myeloid Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00397	Acute Myeloid Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00549	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01217	Other Blood Cancers	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00560	Gastric Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00289	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00233	T-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00316	Glioblastoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00503	Gastric Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00603	Head and Neck Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01033	Bladder Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01695	Acute Myeloid Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01735	Biliary Tract Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01617	Endometrial Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01470	Acute Myeloid Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01460	Glioma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01320	Pancreatic Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01578	Bladder Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00008	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00170	Head and Neck Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01611	Endometrial Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00158	Glioblastoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01573	Plasma Cell Myeloma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01432	Kidney Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01575	Plasma Cell Myeloma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01450	Gastric Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01433	Kidney Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01378	Ovarian Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01685	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM00164	Biliary Tract Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01559	Melanoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01662	Plasma Cell Myeloma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.E422D	SIDM01618	B-Lymphoblastic Leukemia	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.6758
p.M438I	SIDM00107	Melanoma	GDSC	RRISLSDMP	DEG_APCC_DBOX_1	0.5556
p.M438I	UACC-62	skin	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	0.5556
p.G438S	ACH-000999	Colon/Colorectal Cancer	CCLE	RRISLSDMP	DEG_APCC_DBOX_1	0.5556
p.G438S	SNU-1040	large_intestine	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	0.5556
p.R418Q	ACH-001569	Skin Cancer	CCLE	RRISLSDMP	DEG_APCC_DBOX_1	0.2222
p.L421W	ACH-001804	Liposarcoma	CCLE	RRISLSDMP	DEG_APCC_DBOX_1	0.3056
p.G414A	ACH-002317	Leukemia	CCLE	RRISLSDMP	DEG_APCC_DBOX_1	0.1111
p.G414A	YT	haematopoietic_and_lymphoid_tissue	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	0.1111
p.G439A	YT	haematopoietic_and_lymphoid_tissue	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	0.5278
p.F431V	FTC-133	thyroid	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	0.3056
p.M431I	UACC-62	skin	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	0.3056
p.G419A	YT	haematopoietic_and_lymphoid_tissue	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	0.25
p.G418S	SNU-1040	large_intestine	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	0.2222
p.S427N	HCT-15	large_intestine	COSMIC	RRISLSDMP	DEG_APCC_DBOX_1	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRISLSDMP

Degron related mutations and impact score

Drug responses associated with ZMYND8 mutations

All proteins holding degron of RRISLSDMP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULU4	Protein kinase C-binding protein 1	DEG_APCC_DBOX_1	422:430	RRISLSDMP	APC,CDC20,FZR1	0.9597	More...