DegronMD

Uniprot ID: Q9ULU4

Source protein: Protein kinase C-binding protein 1

Source gene: ZMYND8

Class: DEG_SPOP_SBC_1

Location: 747:751

E3 ligase: SPOP

DEGRON score: 0.7904

ASA_SCORE: 90.36

COIL: 0.9344

CONS_SCORE: 0.3928

DSS_SCORE: 0.798

HELIX: 0.0214

FCONS_SCORE: 0.9304

RIG_SCORE: 0.5535

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S756C	DO218173	BRCA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.6389
p.V752A	DO227999	COCA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.V752A	DO229013	COCA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.V752A	DO229016	COCA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.V752A	DO233628	GACA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.V752A	DO229346	LAML	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.V752A	DO229353	LAML	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.V752A	DO228941	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.V752A	DO228947	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.V752A	DO231102	LUSC	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.Q740K	DO229024	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.1389
p.T750S	DO26842	LUSC	ICGC	PPSTT	DEG_SPOP_SBC_1	0.7116
p.D741Y	DO47120	RECA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.1667
p.P747S	DO48652	SKCM	ICGC	PPSTT	DEG_SPOP_SBC_1	0.6752
p.P747S	DO51254	SKCM	ICGC	PPSTT	DEG_SPOP_SBC_1	0.6752
p.G750R	SIDM00181	Bladder Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	0.7568
p.G750R	LB831-BLC	urinary_tract	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.7568
p.S749A	SIDM00274	Gastric Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	0.7588
p.S749A	GCIY	stomach	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.7588
p.T749M	ACH-000493	Liver Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	0.7423
p.T749M	ACH-000967	Colon/Colorectal Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	0.7423
p.T749M	ACH-001199	Colon/Colorectal Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	0.7423
p.T749M	SNU-423	liver	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.7423
p.T749M	SNU-C2B	large_intestine	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.7423
p.Q739H	ACH-002199	Kidney Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	0.2222
p.Q739H	SN12C	kidney	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.2222
p.T754M	SNU-423	liver	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.6944
p.T754M	SNU-C2B	large_intestine	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.6944
p.S742A	GCIY	stomach	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.1944
p.K740N	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.1389
p.R751C	FTC-133	thyroid	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.8301
p.A742T	NCI-H441	lung	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40855	Peroxisomal biogenesis factor 19	DEG_SPOP_SBC_1	38:42	PPSTT	SPOP	0.9672	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	586:590	PPSTT	SPOP	0.827	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1338:1342	PPSTT	SPOP	0.6546	More...
Q12906	Interleukin enhancer-binding factor 3	DEG_SPOP_SBC_1	360:364	PPSTT	SPOP	0.9995	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	557:561	PPSTT	SPOP	0.9894	More...
Q71RC2	La-related protein 4	DEG_SPOP_SBC_1	584:588	PPSTT	SPOP	0.9845	More...
Q7Z410	Transmembrane protease serine 9	DEG_SPOP_SBC_1	744:748	PPSTT	SPOP	0.9917	More...
Q99583	Max-binding protein MNT	DEG_SPOP_SBC_1	370:374	PPSTT	SPOP	0.9764	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	262:266	PPSTT	SPOP	0.9683	More...
Q9BQD3	KxDL motif-containing protein 1	DEG_SPOP_SBC_1	117:121	PPSTT	SPOP	0.9044	More...
Q9UBS0	Ribosomal protein S6 kinase beta-2	DEG_SPOP_SBC_1	455:459	PPSTT	SPOP	0.8411	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4236:4240	PPSTT	SPOP	0.7626	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	747:751	PPSTT	SPOP	0.7904	More...
A3KN83	Protein strawberry notch homolog 1	DEG_SPOP_SBC_1	82:86	PPSTT	SPOP	0.9886	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	163:167	PPSTT	SPOP	0.9599	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	274:278	PPSTT	SPOP	0.994	More...
Q5EBL2	Zinc finger protein 628	DEG_SPOP_SBC_1	650:654	PPSTT	SPOP	0.7452	More...
Q96KJ4	Mesothelin-like protein	DEG_SPOP_SBC_1	608:612	PPSTT	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTT

Degron related mutations and impact score

Drug responses associated with ZMYND8 mutations

All proteins holding degron of PPSTT