DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPSTT
Uniprot ID:
Q68DE3
Source protein:
Basic helix-loop-helix domain-containing protein USF3
Source gene:
USF3
Class:
DEG_SPOP_SBC_1
Location:
557:561
E3 ligase:
SPOP
DEGRON score:
0.9894
ASA_SCORE:
98.52
COIL:
0.975
CONS_SCORE:
0.6303
DSS_SCORE:
0.4326
HELIX:
0.0082
FCONS_SCORE:
1.0391
RIG_SCORE:
0.6992
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with USF3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P40855
Peroxisomal biogenesis factor 19
DEG_SPOP_SBC_1
38:42
PPSTT
SPOP
0.9672
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
586:590
PPSTT
SPOP
0.827
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1338:1342
PPSTT
SPOP
0.6546
More...
Q12906
Interleukin enhancer-binding factor 3
DEG_SPOP_SBC_1
360:364
PPSTT
SPOP
0.9995
More...
Q68DE3
Basic helix-loop-helix domain-containing protein USF3
DEG_SPOP_SBC_1
557:561
PPSTT
SPOP
0.9894
More...
Q71RC2
La-related protein 4
DEG_SPOP_SBC_1
584:588
PPSTT
SPOP
0.9845
More...
Q7Z410
Transmembrane protease serine 9
DEG_SPOP_SBC_1
744:748
PPSTT
SPOP
0.9917
More...
Q99583
Max-binding protein MNT
DEG_SPOP_SBC_1
370:374
PPSTT
SPOP
0.9764
More...
Q99941
Cyclic AMP-dependent transcription factor ATF-6 beta
DEG_SPOP_SBC_1
262:266
PPSTT
SPOP
0.9683
More...
Q9BQD3
KxDL motif-containing protein 1
DEG_SPOP_SBC_1
117:121
PPSTT
SPOP
0.9044
More...
Q9UBS0
Ribosomal protein S6 kinase beta-2
DEG_SPOP_SBC_1
455:459
PPSTT
SPOP
0.8411
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
4236:4240
PPSTT
SPOP
0.7626
More...
Q9ULU4
Protein kinase C-binding protein 1
DEG_SPOP_SBC_1
747:751
PPSTT
SPOP
0.7904
More...
A3KN83
Protein strawberry notch homolog 1
DEG_SPOP_SBC_1
82:86
PPSTT
SPOP
0.9886
More...
Q9ULI4
Kinesin-like protein KIF26A
DEG_SPOP_SBC_1
163:167
PPSTT
SPOP
0.9599
More...
Q2KHR3
Glutamine and serine-rich protein 1
DEG_SPOP_SBC_1
274:278
PPSTT
SPOP
0.994
More...
Q5EBL2
Zinc finger protein 628
DEG_SPOP_SBC_1
650:654
PPSTT
SPOP
0.7452
More...
Q96KJ4
Mesothelin-like protein
DEG_SPOP_SBC_1
608:612
PPSTT
SPOP
0.9833
More...