DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 4236:4240

E3 ligase: SPOP

DEGRON score: 0.7626

ASA_SCORE: 93.56

COIL: 0.9334

CONS_SCORE: 0

DSS_SCORE: 0.6526

HELIX: 0.0134

FCONS_SCORE: 0

RIG_SCORE: 0.5843

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W4226C	DO228948	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.0556
p.V4244F	DO229008	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.2222
p.S4238G	DO224624	LUSC	ICGC	PPSTT	DEG_SPOP_SBC_1	0.6993
p.A4241S	DO232224	PBCA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.T4236N	SIDM00291	Melanoma	GDSC	PPSTT	DEG_SPOP_SBC_1	0.7055
p.T4236N	HMV-II	skin	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.7055
p.T4235A	SIDM00214	Colorectal Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.T4235A	SNU-407	large_intestine	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.E4243Q	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPSTT	DEG_SPOP_SBC_1	0.25
p.E4243Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.25
p.E4243D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPSTT	DEG_SPOP_SBC_1	0.25
p.E4243D	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.25
p.S4249N	SIDM01098	Neuroblastoma	GDSC	PPSTT	DEG_SPOP_SBC_1	0.0833
p.S4249N	UDSCC2	upper_aerodigestive_tract	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.0833
p.S4249N	SK-N-SH	autonomic_ganglia	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.0833
p.Q4242R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.2778
p.E4243K	NCI-H1299	lung	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40855	Peroxisomal biogenesis factor 19	DEG_SPOP_SBC_1	38:42	PPSTT	SPOP	0.9672	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	586:590	PPSTT	SPOP	0.827	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1338:1342	PPSTT	SPOP	0.6546	More...
Q12906	Interleukin enhancer-binding factor 3	DEG_SPOP_SBC_1	360:364	PPSTT	SPOP	0.9995	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	557:561	PPSTT	SPOP	0.9894	More...
Q71RC2	La-related protein 4	DEG_SPOP_SBC_1	584:588	PPSTT	SPOP	0.9845	More...
Q7Z410	Transmembrane protease serine 9	DEG_SPOP_SBC_1	744:748	PPSTT	SPOP	0.9917	More...
Q99583	Max-binding protein MNT	DEG_SPOP_SBC_1	370:374	PPSTT	SPOP	0.9764	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	262:266	PPSTT	SPOP	0.9683	More...
Q9BQD3	KxDL motif-containing protein 1	DEG_SPOP_SBC_1	117:121	PPSTT	SPOP	0.9044	More...
Q9UBS0	Ribosomal protein S6 kinase beta-2	DEG_SPOP_SBC_1	455:459	PPSTT	SPOP	0.8411	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4236:4240	PPSTT	SPOP	0.7626	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	747:751	PPSTT	SPOP	0.7904	More...
A3KN83	Protein strawberry notch homolog 1	DEG_SPOP_SBC_1	82:86	PPSTT	SPOP	0.9886	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	163:167	PPSTT	SPOP	0.9599	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	274:278	PPSTT	SPOP	0.994	More...
Q5EBL2	Zinc finger protein 628	DEG_SPOP_SBC_1	650:654	PPSTT	SPOP	0.7452	More...
Q96KJ4	Mesothelin-like protein	DEG_SPOP_SBC_1	608:612	PPSTT	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons