DegronMD

Uniprot ID: Q9UBS0

Source protein: Ribosomal protein S6 kinase beta-2

Source gene: RPS6KB2

Class: DEG_SPOP_SBC_1

Location: 455:459

E3 ligase: SPOP

DEGRON score: 0.8411

ASA_SCORE: 89.1

COIL: 0.9262

CONS_SCORE: 0.4239

DSS_SCORE: 0.7577

HELIX: 0.0378

FCONS_SCORE: 1.0614

RIG_SCORE: 0.5341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L447V	TCGA-A8-A06Q	BRCA	TCGA	PPSTT	DEG_SPOP_SBC_1	0.1111
p.L447V	DO1263	BRCA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.1111
p.A460T	TCGA-BH-A202	BRCA	TCGA	PPSTT	DEG_SPOP_SBC_1	0.3056
p.A460T	DO4665	BRCA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.A460T	SIDM00333	Endometrial Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.A460T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	0.3056
p.P449A	DO222579	ESCA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.1667
p.P454L	DO231942	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.P454L	SIDM01622	Breast Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	0.3056
p.G469W	SIDM02021	Esophageal Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	0.0556
p.R465C	SIDM00561	Other Blood Cancers	GDSC	PPSTT	DEG_SPOP_SBC_1	0.1667
p.R465C	ACH-001568	Skin Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	0.1667
p.R465C	ACH-002274	Leukemia	CCLE	PPSTT	DEG_SPOP_SBC_1	0.1667
p.R465C	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	PPSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40855	Peroxisomal biogenesis factor 19	DEG_SPOP_SBC_1	38:42	PPSTT	SPOP	0.9672	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	586:590	PPSTT	SPOP	0.827	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1338:1342	PPSTT	SPOP	0.6546	More...
Q12906	Interleukin enhancer-binding factor 3	DEG_SPOP_SBC_1	360:364	PPSTT	SPOP	0.9995	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	557:561	PPSTT	SPOP	0.9894	More...
Q71RC2	La-related protein 4	DEG_SPOP_SBC_1	584:588	PPSTT	SPOP	0.9845	More...
Q7Z410	Transmembrane protease serine 9	DEG_SPOP_SBC_1	744:748	PPSTT	SPOP	0.9917	More...
Q99583	Max-binding protein MNT	DEG_SPOP_SBC_1	370:374	PPSTT	SPOP	0.9764	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	262:266	PPSTT	SPOP	0.9683	More...
Q9BQD3	KxDL motif-containing protein 1	DEG_SPOP_SBC_1	117:121	PPSTT	SPOP	0.9044	More...
Q9UBS0	Ribosomal protein S6 kinase beta-2	DEG_SPOP_SBC_1	455:459	PPSTT	SPOP	0.8411	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4236:4240	PPSTT	SPOP	0.7626	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	747:751	PPSTT	SPOP	0.7904	More...
A3KN83	Protein strawberry notch homolog 1	DEG_SPOP_SBC_1	82:86	PPSTT	SPOP	0.9886	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	163:167	PPSTT	SPOP	0.9599	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	274:278	PPSTT	SPOP	0.994	More...
Q5EBL2	Zinc finger protein 628	DEG_SPOP_SBC_1	650:654	PPSTT	SPOP	0.7452	More...
Q96KJ4	Mesothelin-like protein	DEG_SPOP_SBC_1	608:612	PPSTT	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons