DegronMD - Q9UBS0(RPS6KB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R419W	TCGA-2W-A8YY	CESC	TCGA	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.7523
p.R419W	DO223732	CESC	ICGC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.7523
p.L447V	TCGA-A8-A06Q	BRCA	TCGA	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.L447V	DO1263	BRCA	ICGC	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.A460T	TCGA-BH-A202	BRCA	TCGA	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.3056
p.A460T	DO4665	BRCA	ICGC	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.3056
p.A460T	SIDM00333	Endometrial Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.3056
p.A460T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.3056
p.P429H	TCGA-ER-A19E	SKCM	TCGA	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation rewiring degron network	0.2222
p.P429H	DO47542	SKCM	ICGC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation rewiring degron network	0.2222
p.S410L	TCGA-VS-A9UZ	CESC	TCGA	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation blocking phosphorylation signal	0.5833
p.S410L	DO51646	CESC	ICGC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation blocking phosphorylation signal	0.5833
p.R434W	DO7148	CLLE	ICGC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation rewiring degron network	0.0833
p.V422I	DO44090	COAD	ICGC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.7076
p.V422I	SIDM01257	Hepatocellular Carcinoma	GDSC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.7076
p.V422I	SIDM00062	Hepatocellular Carcinoma	GDSC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.7076
p.V422I	ACH-000671	Liver Cancer	CCLE	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.7076
p.V422I	ACH-002395	Liver Cancer	CCLE	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.7076
p.V422I	HUH-6-clone5	liver	COSMIC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.7076
p.A420V	DO230334	COCA	ICGC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.6936
p.A420V	DO229016	COCA	ICGC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.6936
p.A420V	DO229003	COCA	ICGC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.6936
p.A420V	DO228343	MALY	ICGC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.6936
p.F427V	DO50411	ESAD	ICGC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation rewiring degron network	0.2778
p.P449A	DO222579	ESCA	ICGC	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.P454L	DO231942	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.3056
p.P454L	SIDM01622	Breast Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.3056
p.G469W	SIDM02021	Esophageal Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0556
p.R419Q	SIDM00282	Colorectal Carcinoma	GDSC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.6218
p.R419Q	ACH-000998	Colon/Colorectal Cancer	CCLE	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.6218
p.R419Q	CW-2	large intestine	COSMIC	SPRAPVSPL	DEG_SIAH_1	417:425	Mutation altering degron motif	0.6218
p.R465C	SIDM00561	Other Blood Cancers	GDSC	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.R465C	ACH-001568	Skin Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.R465C	ACH-002274	Leukemia	CCLE	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.R465C	MLMA	haematopoietic and lymphoid tissue	COSMIC	PPSTT	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667

Kaplan plot for RPS6KB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPS6KB2

UniProt ID: Q9UBS0

Entrez ID: 6199

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPS6KB2 in