DegronMD

Uniprot ID: Q9UBS0

Source protein: Ribosomal protein S6 kinase beta-2

Source gene: RPS6KB2

Class: DEG_SIAH_1

Location: 417:425

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9974

ASA_SCORE: 83.6333

COIL: 0.9256

CONS_SCORE: 0.4235

DSS_SCORE: 0.4949

HELIX: 0.0533

FCONS_SCORE: 1.0255

RIG_SCORE: 0.6073

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R419W	TCGA-2W-A8YY	CESC	TCGA	SPRAPVSPL	DEG_SIAH_1	0.7523
p.R419W	DO223732	CESC	ICGC	SPRAPVSPL	DEG_SIAH_1	0.7523
p.P429H	TCGA-ER-A19E	SKCM	TCGA	SPRAPVSPL	DEG_SIAH_1	0.2222
p.P429H	DO47542	SKCM	ICGC	SPRAPVSPL	DEG_SIAH_1	0.2222
p.S410L	TCGA-VS-A9UZ	CESC	TCGA	SPRAPVSPL	DEG_SIAH_1	0.5833
p.S410L	DO51646	CESC	ICGC	SPRAPVSPL	DEG_SIAH_1	0.5833
p.R434W	DO7148	CLLE	ICGC	SPRAPVSPL	DEG_SIAH_1	0.0833
p.V422I	DO44090	COAD	ICGC	SPRAPVSPL	DEG_SIAH_1	0.7076
p.V422I	SIDM01257	Hepatocellular Carcinoma	GDSC	SPRAPVSPL	DEG_SIAH_1	0.7076
p.V422I	SIDM00062	Hepatocellular Carcinoma	GDSC	SPRAPVSPL	DEG_SIAH_1	0.7076
p.V422I	ACH-000671	Liver Cancer	CCLE	SPRAPVSPL	DEG_SIAH_1	0.7076
p.V422I	ACH-002395	Liver Cancer	CCLE	SPRAPVSPL	DEG_SIAH_1	0.7076
p.V422I	HUH-6-clone5	liver	COSMIC	SPRAPVSPL	DEG_SIAH_1	0.7076
p.A420V	DO230334	COCA	ICGC	SPRAPVSPL	DEG_SIAH_1	0.6936
p.A420V	DO229016	COCA	ICGC	SPRAPVSPL	DEG_SIAH_1	0.6936
p.A420V	DO229003	COCA	ICGC	SPRAPVSPL	DEG_SIAH_1	0.6936
p.A420V	DO228343	MALY	ICGC	SPRAPVSPL	DEG_SIAH_1	0.6936
p.F427V	DO50411	ESAD	ICGC	SPRAPVSPL	DEG_SIAH_1	0.2778
p.R419Q	SIDM00282	Colorectal Carcinoma	GDSC	SPRAPVSPL	DEG_SIAH_1	0.6218
p.R419Q	ACH-000998	Colon/Colorectal Cancer	CCLE	SPRAPVSPL	DEG_SIAH_1	0.6218
p.R419Q	CW-2	large_intestine	COSMIC	SPRAPVSPL	DEG_SIAH_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBS0	Ribosomal protein S6 kinase beta-2	DEG_SIAH_1	417:425	SPRAPVSPL	SIAH1,SIAH2,SIAH3	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons