DegronMD - Q5EBL2(ZNF628)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G659D	TCGA-IB-7651	PAAD	TCGA	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation rewiring degron network	0.1667
p.G659D	TCGA-IB-7651	PAAD	TCGA	PPSTT	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1944
p.G659D	DO46657	PAAD	ICGC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation rewiring degron network	0.1667
p.G659D	DO46657	PAAD	ICGC	PPSTT	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1944
p.A658T	DO230326	COCA	ICGC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation rewiring degron network	0.1944
p.A658T	DO230326	COCA	ICGC	PPSTT	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.2222
p.A658T	DO42673	UCEC	ICGC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation rewiring degron network	0.1944
p.A658T	DO42673	UCEC	ICGC	PPSTT	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.2222
p.L637V	DO50315	ESAD	ICGC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation rewiring degron network	0.0833
p.P662A	DO233670	GACA	ICGC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation rewiring degron network	0.0833
p.P662A	DO233670	GACA	ICGC	PPSTT	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1111
p.R639Q	DO233855	GACA	ICGC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation rewiring degron network	0.1389
p.P646S	DO232761	PBCA	ICGC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation altering degron motif	0.6752
p.P646A	SIDM01009	Neuroblastoma	GDSC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation altering degron motif	0.7503
p.P646A	ACH-000259	Neuroblastoma	CCLE	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation altering degron motif	0.7503
p.P646A	KELLY	autonomic ganglia	COSMIC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation altering degron motif	0.7503
p.A657V	SIDM01752	Pancreatic Carcinoma	GDSC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation rewiring degron network	0.2222
p.A657V	SIDM01752	Pancreatic Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.25
p.P646L	ACH-000512	Myeloma	CCLE	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation altering degron motif	0.6471
p.A657G	ACH-000868	Lung Cancer	CCLE	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation rewiring degron network	0.2222
p.A657G	ACH-000868	Lung Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.25
p.P651L	ACH-000987	Skin Cancer	CCLE	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation altering degron motif	0.6471
p.P651L	ACH-000987	Skin Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	650:654	Mutation altering degron motif	0.6471
p.P645A	KELLY	autonomic ganglia	COSMIC	PANTPPST	DEG_SCF_FBW7_1	646:653	Mutation rewiring degron network	0.3056
p.P645A	KELLY	autonomic ganglia	COSMIC	PPSTT	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1944

Kaplan plot for ZNF628 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF628

UniProt ID: Q5EBL2

Entrez ID: 89887

Protein name: Zinc finger protein 628

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZNF628 in