DegronMD

Uniprot ID: Q5EBL2

Source protein: Zinc finger protein 628

Source gene: ZNF628

Class: DEG_SCF_FBW7_1

Location: 646:653

E3 ligase: FBXW7

DEGRON score: 0.8332

ASA_SCORE: 72.1125

COIL: 0.8676

CONS_SCORE: 0.3784

DSS_SCORE: 0.7002

HELIX: 0.03

FCONS_SCORE: 0.5714

RIG_SCORE: 0.5785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G659D	TCGA-IB-7651	PAAD	TCGA	PANTPPST	DEG_SCF_FBW7_1	0.1667
p.G659D	DO46657	PAAD	ICGC	PANTPPST	DEG_SCF_FBW7_1	0.1667
p.A658T	DO230326	COCA	ICGC	PANTPPST	DEG_SCF_FBW7_1	0.1944
p.A658T	DO42673	UCEC	ICGC	PANTPPST	DEG_SCF_FBW7_1	0.1944
p.L637V	DO50315	ESAD	ICGC	PANTPPST	DEG_SCF_FBW7_1	0.0833
p.P662A	DO233670	GACA	ICGC	PANTPPST	DEG_SCF_FBW7_1	0.0833
p.R639Q	DO233855	GACA	ICGC	PANTPPST	DEG_SCF_FBW7_1	0.1389
p.P646S	DO232761	PBCA	ICGC	PANTPPST	DEG_SCF_FBW7_1	0.6752
p.P646A	SIDM01009	Neuroblastoma	GDSC	PANTPPST	DEG_SCF_FBW7_1	0.7503
p.P646A	ACH-000259	Neuroblastoma	CCLE	PANTPPST	DEG_SCF_FBW7_1	0.7503
p.P646A	KELLY	autonomic_ganglia	COSMIC	PANTPPST	DEG_SCF_FBW7_1	0.7503
p.A657V	SIDM01752	Pancreatic Carcinoma	GDSC	PANTPPST	DEG_SCF_FBW7_1	0.2222
p.P646L	ACH-000512	Myeloma	CCLE	PANTPPST	DEG_SCF_FBW7_1	0.6471
p.A657G	ACH-000868	Lung Cancer	CCLE	PANTPPST	DEG_SCF_FBW7_1	0.2222
p.P651L	ACH-000987	Skin Cancer	CCLE	PANTPPST	DEG_SCF_FBW7_1	0.6471
p.P645A	KELLY	autonomic_ganglia	COSMIC	PANTPPST	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5EBL2	Zinc finger protein 628	DEG_SCF_FBW7_1	646:653	PANTPPST	FBXW7	0.8332	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons