DegronMD - Q7Z410(TMPRSS9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S746L	TCGA-63-5131	LUSC	TCGA	PPSTT	DEG_SPOP_SBC_1	744:748	Mutation altering degron motif	0.7667
p.S746L	DO26898	LUSC	ICGC	PPSTT	DEG_SPOP_SBC_1	744:748	Mutation altering degron motif	0.7667
p.E462D	TCGA-B5-A0JY	UCEC	TCGA	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation rewiring degron network	0.25
p.E462D	DO43041	UCEC	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation rewiring degron network	0.25
p.T758M	TCGA-BA-A6DD	HNSC	TCGA	PPSTT	DEG_SPOP_SBC_1	744:748	Mutation blocking phosphorylation signal	0.5
p.T758M	DO44452	HNSC	ICGC	PPSTT	DEG_SPOP_SBC_1	744:748	Mutation blocking phosphorylation signal	0.5
p.T800M	TCGA-BR-4256	STAD	TCGA	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1944
p.T800M	DO38743	STAD	ICGC	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1944
p.S472L	TCGA-BR-8680	STAD	TCGA	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation altering degron motif	0.7667
p.S472L	TCGA-EO-A22R	UCEC	TCGA	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation altering degron motif	0.7667
p.S472L	DO47769	STAD	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation altering degron motif	0.7667
p.S472L	DO42713	UCEC	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation altering degron motif	0.7667
p.P756R	TCGA-BR-A44U	STAD	TCGA	PPSTT	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1111
p.P756R	DO47921	STAD	ICGC	PPSTT	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1111
p.P469S	TCGA-CU-A0YN	BLCA	TCGA	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation altering degron motif	0.6752
p.P469S	DO488	BLCA	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation altering degron motif	0.6752
p.S467N	TCGA-DD-AAVS	LIHC	TCGA	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation altering degron motif	0.5958
p.S467N	DO52279	LIHC	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation altering degron motif	0.5958
p.G798E	TCGA-EE-A2GC	SKCM	TCGA	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.G798E	DO37839	SKCM	ICGC	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.L740I	DO230336	COCA	ICGC	PPSTT	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.2222
p.V479M	DO222503	COCA	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation rewiring degron network	0.1389
p.S793N	DO229003	COCA	ICGC	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation altering degron motif	0.7069
p.S793N	DO231140	LAML	ICGC	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation altering degron motif	0.7069
p.S793N	DO230937	LUSC	ICGC	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation altering degron motif	0.7069
p.T748I	DO222624	ESCA	ICGC	PPSTT	DEG_SPOP_SBC_1	744:748	Mutation altering degron motif	0.7078
p.P803A	DO231051	LUSC	ICGC	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1111
p.T470I	DO232838	NACA	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation altering degron motif	0.5966
p.T794N	DO229248	THCA	ICGC	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation altering degron motif	0.7055
p.T781M	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.5
p.T781M	ACH-000865	Esophageal Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.5
p.D804N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0833
p.D804N	ACH-002222	Leukemia	CCLE	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0833
p.D804N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AVSTT	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0833
p.T468N	ACH-000251	Lung Cancer	CCLE	VVSTPTKS	DEG_SCF_FBW7_1	465:472	Mutation altering degron motif	0.7055

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMPRSS9

UniProt ID: Q7Z410

Entrez ID: 360200

Protein name: Transmembrane protease serine 9 (EC 3.4.21.-) (Polyserase-I) (Polyserine protease 1) (Polyserase-1) [Cleaved into: Serase-1; Serase-2; Serase-3]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMPRSS9 in