DegronMD

Uniprot ID: Q7Z410

Source protein: Transmembrane protease serine 9

Source gene: TMPRSS9

Class: DEG_SCF_FBW7_1

Location: 465:472

E3 ligase: FBXW7

DEGRON score: 0.8956

ASA_SCORE: 61.025

COIL: 0.7673

CONS_SCORE: 0.4147

DSS_SCORE: 0.5228

HELIX: 0.0985

FCONS_SCORE: 1.0213

RIG_SCORE: 0.693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E462D	TCGA-B5-A0JY	UCEC	TCGA	VVSTPTKS	DEG_SCF_FBW7_1	0.25
p.E462D	DO43041	UCEC	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	0.25
p.S472L	TCGA-BR-8680	STAD	TCGA	VVSTPTKS	DEG_SCF_FBW7_1	0.7667
p.S472L	TCGA-EO-A22R	UCEC	TCGA	VVSTPTKS	DEG_SCF_FBW7_1	0.7667
p.S472L	DO47769	STAD	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	0.7667
p.S472L	DO42713	UCEC	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	0.7667
p.P469S	TCGA-CU-A0YN	BLCA	TCGA	VVSTPTKS	DEG_SCF_FBW7_1	0.6752
p.P469S	DO488	BLCA	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	0.6752
p.S467N	TCGA-DD-AAVS	LIHC	TCGA	VVSTPTKS	DEG_SCF_FBW7_1	0.5958
p.S467N	DO52279	LIHC	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	0.5958
p.V479M	DO222503	COCA	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	0.1389
p.T470I	DO232838	NACA	ICGC	VVSTPTKS	DEG_SCF_FBW7_1	0.5966
p.T468N	ACH-000251	Lung Cancer	CCLE	VVSTPTKS	DEG_SCF_FBW7_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z410	Transmembrane protease serine 9	DEG_SCF_FBW7_1	465:472	VVSTPTKS	FBXW7	0.8956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons