DegronMD

Uniprot ID: Q9ULU4

Source protein: Protein kinase C-binding protein 1

Source gene: ZMYND8

Class: DEG_SCF_FBW7_1

Location: 743:750

E3 ligase: FBXW7

DEGRON score: 0.7823

ASA_SCORE: 91.2875

COIL: 0.9505

CONS_SCORE: 0.3945

DSS_SCORE: 0.7942

HELIX: 0.019

FCONS_SCORE: 0.9412

RIG_SCORE: 0.5604

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D736Y	TCGA-AP-A051	UCEC	TCGA	VGKTPPST	DEG_SCF_FBW7_1	0.1389
p.R744W	TCGA-HU-A4GQ	STAD	TCGA	VGKTPPST	DEG_SCF_FBW7_1	0.8634
p.S756C	DO218173	BRCA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.6111
p.V752A	DO227999	COCA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.2778
p.V752A	DO229013	COCA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.2778
p.V752A	DO229016	COCA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.2778
p.V752A	DO233628	GACA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.2778
p.V752A	DO229346	LAML	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.2778
p.V752A	DO229353	LAML	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.2778
p.V752A	DO228941	LICA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.2778
p.V752A	DO228947	LICA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.2778
p.V752A	DO231102	LUSC	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.2778
p.Q740K	DO229024	LICA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.25
p.T750S	DO26842	LUSC	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.7116
p.D741Y	DO47120	RECA	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.2778
p.P747S	DO48652	SKCM	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.6752
p.P747S	DO51254	SKCM	ICGC	VGKTPPST	DEG_SCF_FBW7_1	0.6752
p.G750R	SIDM00181	Bladder Carcinoma	GDSC	VGKTPPST	DEG_SCF_FBW7_1	0.7568
p.G750R	LB831-BLC	urinary_tract	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.7568
p.S749A	SIDM00274	Gastric Carcinoma	GDSC	VGKTPPST	DEG_SCF_FBW7_1	0.6477
p.S749A	GCIY	stomach	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.6477
p.D733E	SIDM00490	Glioma	GDSC	VGKTPPST	DEG_SCF_FBW7_1	0.0556
p.D733E	Becker	central_nervous_system	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.0556
p.T749M	ACH-000493	Liver Cancer	CCLE	VGKTPPST	DEG_SCF_FBW7_1	0.7423
p.T749M	ACH-000967	Colon/Colorectal Cancer	CCLE	VGKTPPST	DEG_SCF_FBW7_1	0.7423
p.T749M	ACH-001199	Colon/Colorectal Cancer	CCLE	VGKTPPST	DEG_SCF_FBW7_1	0.7423
p.T749M	SNU-423	liver	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.7423
p.T749M	SNU-C2B	large_intestine	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.7423
p.Q739H	ACH-002199	Kidney Cancer	CCLE	VGKTPPST	DEG_SCF_FBW7_1	0.3333
p.Q739H	SN12C	kidney	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.3333
p.G743R	LB831-BLC	urinary_tract	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.7568
p.T754M	SNU-423	liver	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.6667
p.T754M	SNU-C2B	large_intestine	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.6667
p.S742A	GCIY	stomach	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.3056
p.K740N	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.25
p.A742T	NCI-H441	lung	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.3056
p.L745F	SW403	large_intestine	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.6981
p.T736M	NCI-H23	lung	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.1389
p.Q744H	SN12C	kidney	COSMIC	VGKTPPST	DEG_SCF_FBW7_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGKTPPST

Degron related mutations and impact score

Drug responses associated with ZMYND8 mutations

All proteins holding degron of VGKTPPST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULU4	Protein kinase C-binding protein 1	DEG_SCF_FBW7_1	743:750	VGKTPPST	FBXW7	0.7823	More...