DegronMD - Q99856(ARID3A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A578V	TCGA-A5-A0G1	UCEC	TCGA	LSTPSTS	DEG_SCF_FBW7_1	580:586	Mutation rewiring degron network	0.2778
p.A578V	TCGA-A5-A0G1	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.1944
p.A578V	DO42472	UCEC	ICGC	LSTPSTS	DEG_SCF_FBW7_1	580:586	Mutation rewiring degron network	0.2778
p.A578V	DO42472	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.1944
p.A578V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LSTPSTS	DEG_SCF_FBW7_1	580:586	Mutation rewiring degron network	0.2778
p.A578V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSTST	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.1944
p.A578V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LSTPSTS	DEG_SCF_FBW7_1	580:586	Mutation rewiring degron network	0.2778
p.A578V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSTST	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.1944
p.S591L	TCGA-QQ-A8VG	SARC	TCGA	LSTPSTS	DEG_SCF_FBW7_1	580:586	Mutation blocking phosphorylation signal	0.6389
p.S591L	TCGA-QQ-A8VG	SARC	TCGA	PSTST	DEG_SPOP_SBC_1	583:587	Mutation blocking phosphorylation signal	0.6667
p.S591L	DO220260	SARC	ICGC	LSTPSTS	DEG_SCF_FBW7_1	580:586	Mutation blocking phosphorylation signal	0.6389
p.S591L	DO220260	SARC	ICGC	PSTST	DEG_SPOP_SBC_1	583:587	Mutation blocking phosphorylation signal	0.6667
p.G573S	DO225337	BRCA	ICGC	LSTPSTS	DEG_SCF_FBW7_1	580:586	Mutation rewiring degron network	0.1389
p.G573S	DO225337	BRCA	ICGC	PSTST	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.0556
p.G572S	DO227549	COCA	ICGC	LSTPSTS	DEG_SCF_FBW7_1	580:586	Mutation rewiring degron network	0.1111
p.S586F	ACH-000805	Skin Cancer	CCLE	LSTPSTS	DEG_SCF_FBW7_1	580:586	Mutation altering degron motif	0.7982
p.S586F	ACH-000805	Skin Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	583:587	Mutation altering degron motif	0.7982

Kaplan plot for ARID3A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARID3A

UniProt ID: Q99856

Entrez ID: 1820

Protein name: AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARID3A in