DegronMD

Uniprot ID: Q99856

Source protein: AT-rich interactive domain-containing protein 3A

Source gene: ARID3A

Class: DEG_SCF_FBW7_1

Location: 580:586

E3 ligase: FBXW7

DEGRON score: 0.9451

ASA_SCORE: 93.2857

COIL: 0.9609

CONS_SCORE: 0.273

DSS_SCORE: 0.7594

HELIX: 0.0207

FCONS_SCORE: 0.8489

RIG_SCORE: 0.5893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A578V	TCGA-A5-A0G1	UCEC	TCGA	LSTPSTS	DEG_SCF_FBW7_1	0.2778
p.A578V	DO42472	UCEC	ICGC	LSTPSTS	DEG_SCF_FBW7_1	0.2778
p.A578V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LSTPSTS	DEG_SCF_FBW7_1	0.2778
p.A578V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPSTS	DEG_SCF_FBW7_1	0.2778
p.S591L	TCGA-QQ-A8VG	SARC	TCGA	LSTPSTS	DEG_SCF_FBW7_1	0.6389
p.S591L	DO220260	SARC	ICGC	LSTPSTS	DEG_SCF_FBW7_1	0.6389
p.G573S	DO225337	BRCA	ICGC	LSTPSTS	DEG_SCF_FBW7_1	0.1389
p.G572S	DO227549	COCA	ICGC	LSTPSTS	DEG_SCF_FBW7_1	0.1111
p.S586F	ACH-000805	Skin Cancer	CCLE	LSTPSTS	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99856	AT-rich interactive domain-containing protein 3A	DEG_SCF_FBW7_1	580:586	LSTPSTS	FBXW7	0.9451	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons