DegronMD - Q7Z3K3(POGZ)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F301S	TCGA-5M-AAT6	COAD	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.25
p.G276V	TCGA-AP-A1DK	UCEC	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.0556
p.G276C	TCGA-AP-A1DK	UCEC	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.0556
p.P431S	TCGA-CV-7568	HNSC	TCGA	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.3056
p.P431S	SIDM00545	Melanoma	GDSC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.3056
p.P431S	Mewo	skin	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.3056
p.T262I	TCGA-DU-6392	LGG	TCGA	PSTST	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1944
p.P291L	TCGA-FW-A3R5	SKCM	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.6471
p.T282M	TCGA-LN-A8I0	ESCA	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation blocking phosphorylation signal	0.6667
p.T303A	TCGA-WE-A8K5	SKCM	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.1944
p.S244F	TCGA-XF-AAMG	BLCA	TCGA	PSTST	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.0833
p.D406N	DO44069	BLCA	ICGC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation substituting flanking lysine	0.3333
p.K427R	DO51227	BRCA	ICGC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1389
p.K427R	DO51227	BRCA	ICGC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1944
p.F248S	DO223703	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1944
p.V404M	DO227987	COCA	ICGC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1667
p.E259K	DO234197	ESAD	ICGC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.2778
p.E259K	DO36881	READ	ICGC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.2778
p.E259K	DO43755	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.2778
p.Q296E	DO219080	HNSC	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.6744
p.G300R	DO20633	KIRC	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.2778
p.P435R	DO50737	LICA	ICGC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.7512
p.T439I	DO23356	LINC	ICGC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.8189
p.F419V	DO23356	LINC	ICGC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation altering degron motif	0.7068
p.F419V	DO223286	UCEC	ICGC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation altering degron motif	0.7068
p.P281A	DO23525	LIRI	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation blocking phosphorylation signal	0.6389
p.S303F	DO23525	LIRI	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.1944
p.V428A	DO45552	LUSC	ICGC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation substituting flanking lysine	0.2222
p.V428A	DO45552	LUSC	ICGC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation substituting flanking lysine	0.3333
p.A265T	DO222837	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1111
p.A265T	DO42673	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1111
p.N403S	DO35242	PACA	ICGC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1389
p.T257I	DO232761	PBCA	ICGC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation altering degron motif	0.7078
p.A292V	DO37410	SKCM	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.6936
p.S304L	DO37406	SKCM	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.1667
p.K448Q	DO47449	SKCM	ICGC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation blocking phosphorylation signal	0.5278
p.H293N	DO47353	SKCM	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.7423
p.T250A	DO51282	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation substituting flanking lysine	0.3611
p.R442Q	DO219773	UCEC	ICGC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.25
p.R423W	DO41199	UCEC	ICGC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.25
p.R423W	DO41199	UCEC	ICGC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.0833
p.P446L	SIDM00216	Colorectal Carcinoma	GDSC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1389
p.P446L	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1389
p.P446L	SNU-175	large intestine	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1389
p.P446L	HOP-62	lung	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1389
p.P284S	SIDM01062	Breast Carcinoma	GDSC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.2778
p.P284S	ACH-000643	Breast Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.2778
p.P284S	HDQ-P1	breast	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.2778
p.S410F	SIDM00007	Other Solid Cancers	GDSC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation altering degron motif	0.9093
p.S410F	MCC13	skin	COSMIC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation altering degron motif	0.9093
p.L411R	SIDM01188	Pancreatic Carcinoma	GDSC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation altering degron motif	0.7316
p.L411R	SU8686	pancreas	COSMIC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation altering degron motif	0.7316
p.P291S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.5641
p.P291S	ACH-000904	Lung Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.5641
p.P291S	ACH-001362	Lung Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.5641
p.P291S	NCI-H1770	lung	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.5641
p.R306Q	SIDM00534	Colorectal Carcinoma	GDSC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.1111
p.R306Q	HT-115	large intestine	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.1111
p.L444V	SIDM00158	Glioblastoma	GDSC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.1944
p.L402R	ACH-000114	Pancreatic Cancer	CCLE	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1111
p.L402R	SU8686	pancreas	COSMIC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1111
p.L435V	ACH-000623	Brain Cancer	CCLE	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.6765
p.P437L	ACH-000861	Lung Cancer	CCLE	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.7582
p.P437L	ACH-000989	Colon/Colorectal Cancer	CCLE	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.7582
p.P437L	HOP-62	lung	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.7582
p.P437L	SNU-175	large intestine	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.7582
p.R297Q	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.7329
p.R297Q	HT-115	large intestine	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.7329
p.P422S	ACH-000987	Skin Cancer	CCLE	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation substituting flanking lysine	0.1667
p.P422S	Mewo	skin	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation substituting flanking lysine	0.1667
p.S401F	ACH-001550	Skin Cancer	CCLE	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.0833
p.S401F	MCC13	skin	COSMIC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.0833
p.R407K	COLO-684	endometrium	COSMIC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation substituting flanking lysine	0.3611
p.A407V	SW684	soft tissue	COSMIC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation substituting flanking lysine	0.3611
p.K448R	D-423MG	central nervous system	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation blocking phosphorylation signal	0.5278
p.S267F	U-118-MG	central nervous system	COSMIC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.0556
p.R244Q	HT-115	large intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.0833
p.R440K	COLO-684	endometrium	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation rewiring degron network	0.3056
p.Q449H	NCI-H196	lung	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation substituting flanking lysine	0.1667
p.R449K	COLO-684	endometrium	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation substituting flanking lysine	0.1667
p.V422I	AGS	stomach	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation substituting flanking lysine	0.1667
p.K406R	D-423MG	central nervous system	COSMIC	SLDSEPSVPSA	DEG_COP1_1	410:420	Mutation substituting flanking lysine	0.3333
p.R290C	A253	salivary gland	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.8301
p.K439R	D-423MG	central nervous system	COSMIC	VASTPSST	DEG_SCF_FBW7_1	432:439	Mutation altering degron motif	0.7237
p.R253Q	HT-115	large intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	253:257	Mutation altering degron motif	0.7329
p.S276F	U-118-MG	central nervous system	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POGZ

UniProt ID: Q7Z3K3

Entrez ID: 23126

Protein name: Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POGZ in