DegronMD

Uniprot ID: Q7Z3K3

Source protein: Pogo transposable element with ZNF domain

Source gene: POGZ

Class: DEG_COP1_1

Location: 410:420

E3 ligase: COP1

DEGRON score: 0.9911

ASA_SCORE: 83.7818

COIL: 0.9164

CONS_SCORE: 0.3877

DSS_SCORE: 0.6129

HELIX: 0.0481

FCONS_SCORE: 1.03

RIG_SCORE: 0.6049

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D406N	DO44069	BLCA	ICGC	SLDSEPSVPSA	DEG_COP1_1	0.3333
p.K427R	DO51227	BRCA	ICGC	SLDSEPSVPSA	DEG_COP1_1	0.1389
p.V404M	DO227987	COCA	ICGC	SLDSEPSVPSA	DEG_COP1_1	0.1667
p.F419V	DO23356	LINC	ICGC	SLDSEPSVPSA	DEG_COP1_1	0.7068
p.F419V	DO223286	UCEC	ICGC	SLDSEPSVPSA	DEG_COP1_1	0.7068
p.V428A	DO45552	LUSC	ICGC	SLDSEPSVPSA	DEG_COP1_1	0.2222
p.N403S	DO35242	PACA	ICGC	SLDSEPSVPSA	DEG_COP1_1	0.1389
p.R423W	DO41199	UCEC	ICGC	SLDSEPSVPSA	DEG_COP1_1	0.25
p.S410F	SIDM00007	Other Solid Cancers	GDSC	SLDSEPSVPSA	DEG_COP1_1	0.9093
p.S410F	MCC13	skin	COSMIC	SLDSEPSVPSA	DEG_COP1_1	0.9093
p.L411R	SIDM01188	Pancreatic Carcinoma	GDSC	SLDSEPSVPSA	DEG_COP1_1	0.7316
p.L411R	SU8686	pancreas	COSMIC	SLDSEPSVPSA	DEG_COP1_1	0.7316
p.L402R	ACH-000114	Pancreatic Cancer	CCLE	SLDSEPSVPSA	DEG_COP1_1	0.1111
p.L402R	SU8686	pancreas	COSMIC	SLDSEPSVPSA	DEG_COP1_1	0.1111
p.S401F	ACH-001550	Skin Cancer	CCLE	SLDSEPSVPSA	DEG_COP1_1	0.0833
p.S401F	MCC13	skin	COSMIC	SLDSEPSVPSA	DEG_COP1_1	0.0833
p.R407K	COLO-684	endometrium	COSMIC	SLDSEPSVPSA	DEG_COP1_1	0.3611
p.A407V	SW684	soft_tissue	COSMIC	SLDSEPSVPSA	DEG_COP1_1	0.3611
p.K406R	D-423MG	central_nervous_system	COSMIC	SLDSEPSVPSA	DEG_COP1_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3K3	Pogo transposable element with ZNF domain	DEG_COP1_1	410:420	SLDSEPSVPSA	COP1	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons