DegronMD

Uniprot ID: Q7Z3K3

Source protein: Pogo transposable element with ZNF domain

Source gene: POGZ

Class: DEG_ODPH_VHL_1

Location: 286:298

E3 ligase: VHL

DEGRON score: 0.9989

ASA_SCORE: 78.3923

COIL: 0.8191

CONS_SCORE: 0.401

DSS_SCORE: 0.4854

HELIX: 0.0352

FCONS_SCORE: 0.994

RIG_SCORE: 0.6659

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R290C	A253	salivary_gland	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.8301
p.H293N	DO47353	SKCM	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.7423
p.R297Q	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.7329
p.R297Q	HT-115	large_intestine	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.7329
p.A292V	DO37410	SKCM	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.6936
p.Q296E	DO219080	HNSC	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.6744
p.T282M	TCGA-LN-A8I0	ESCA	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.6667
p.P291L	TCGA-FW-A3R5	SKCM	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.6471
p.P281A	DO23525	LIRI	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.6389
p.P291S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.5641
p.P291S	ACH-000904	Lung Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.5641
p.P291S	ACH-001362	Lung Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.5641
p.P291S	NCI-H1770	lung	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.5641
p.G300R	DO20633	KIRC	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.2778
p.P284S	SIDM01062	Breast Carcinoma	GDSC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.2778
p.P284S	ACH-000643	Breast Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.2778
p.P284S	HDQ-P1	breast	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.2778
p.F301S	TCGA-5M-AAT6	COAD	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.25
p.T303A	TCGA-WE-A8K5	SKCM	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.1944
p.S303F	DO23525	LIRI	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.1944
p.S304L	DO37406	SKCM	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.1667
p.R306Q	SIDM00534	Colorectal Carcinoma	GDSC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.1111
p.R306Q	HT-115	large_intestine	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.1111
p.G276V	TCGA-AP-A1DK	UCEC	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.0556
p.G276C	TCGA-AP-A1DK	UCEC	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.0556

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Drug responses associated with POGZ mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LAPSFPSPPAVSI

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3K3	Pogo transposable element with ZNF domain	DEG_ODPH_VHL_1	286:298	LAPSFPSPPAVSI	VHL	0.9989	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPSFPSPPAVSI

Degron related mutations and impact score

Drug responses associated with POGZ mutations

All proteins holding degron of LAPSFPSPPAVSI