DegronMD

Uniprot ID: Q7Z3K3

Source protein: Pogo transposable element with ZNF domain

Source gene: POGZ

Class: DEG_ODPH_VHL_1

Location: 286:298

E3 ligase: VHL

DEGRON score: 0.9989

ASA_SCORE: 78.3923

COIL: 0.8191

CONS_SCORE: 0.401

DSS_SCORE: 0.4854

HELIX: 0.0352

FCONS_SCORE: 0.994

RIG_SCORE: 0.6659

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F301S	TCGA-5M-AAT6	COAD	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.25
p.G276V	TCGA-AP-A1DK	UCEC	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.0556
p.G276C	TCGA-AP-A1DK	UCEC	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.0556
p.P291L	TCGA-FW-A3R5	SKCM	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.6471
p.T282M	TCGA-LN-A8I0	ESCA	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.6667
p.T303A	TCGA-WE-A8K5	SKCM	TCGA	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.1944
p.Q296E	DO219080	HNSC	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.6744
p.G300R	DO20633	KIRC	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.2778
p.P281A	DO23525	LIRI	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.6389
p.S303F	DO23525	LIRI	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.1944
p.A292V	DO37410	SKCM	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.6936
p.S304L	DO37406	SKCM	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.1667
p.H293N	DO47353	SKCM	ICGC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.7423
p.P284S	SIDM01062	Breast Carcinoma	GDSC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.2778
p.P284S	ACH-000643	Breast Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.2778
p.P284S	HDQ-P1	breast	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.2778
p.P291S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.5641
p.P291S	ACH-000904	Lung Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.5641
p.P291S	ACH-001362	Lung Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.5641
p.P291S	NCI-H1770	lung	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.5641
p.R306Q	SIDM00534	Colorectal Carcinoma	GDSC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.1111
p.R306Q	HT-115	large_intestine	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.1111
p.R297Q	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.7329
p.R297Q	HT-115	large_intestine	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.7329
p.R290C	A253	salivary_gland	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.8301
p.S276F	U-118-MG	central_nervous_system	COSMIC	LAPSFPSPPAVSI	DEG_ODPH_VHL_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPSFPSPPAVSI

Degron related mutations and impact score

Drug responses associated with POGZ mutations

All proteins holding degron of LAPSFPSPPAVSI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3K3	Pogo transposable element with ZNF domain	DEG_ODPH_VHL_1	286:298	LAPSFPSPPAVSI	VHL	0.9989	More...