DegronMD

Uniprot ID: Q7Z3K3

Source protein: Pogo transposable element with ZNF domain

Source gene: POGZ

Class: DEG_SCF_FBW7_1

Location: 432:439

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 78.8875

COIL: 0.9381

CONS_SCORE: 0.4471

DSS_SCORE: 0.666

HELIX: 0.0324

FCONS_SCORE: 1.1028

RIG_SCORE: 0.5551

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P431S	TCGA-CV-7568	HNSC	TCGA	VASTPSST	DEG_SCF_FBW7_1	0.3056
p.P431S	SIDM00545	Melanoma	GDSC	VASTPSST	DEG_SCF_FBW7_1	0.3056
p.P431S	Mewo	skin	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.3056
p.K427R	DO51227	BRCA	ICGC	VASTPSST	DEG_SCF_FBW7_1	0.1944
p.P435R	DO50737	LICA	ICGC	VASTPSST	DEG_SCF_FBW7_1	0.7512
p.T439I	DO23356	LINC	ICGC	VASTPSST	DEG_SCF_FBW7_1	0.8189
p.V428A	DO45552	LUSC	ICGC	VASTPSST	DEG_SCF_FBW7_1	0.3333
p.K448Q	DO47449	SKCM	ICGC	VASTPSST	DEG_SCF_FBW7_1	0.5278
p.R442Q	DO219773	UCEC	ICGC	VASTPSST	DEG_SCF_FBW7_1	0.25
p.R423W	DO41199	UCEC	ICGC	VASTPSST	DEG_SCF_FBW7_1	0.0833
p.P446L	SIDM00216	Colorectal Carcinoma	GDSC	VASTPSST	DEG_SCF_FBW7_1	0.1389
p.P446L	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	VASTPSST	DEG_SCF_FBW7_1	0.1389
p.P446L	SNU-175	large_intestine	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.1389
p.P446L	HOP-62	lung	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.1389
p.L444V	SIDM00158	Glioblastoma	GDSC	VASTPSST	DEG_SCF_FBW7_1	0.1944
p.L435V	ACH-000623	Brain Cancer	CCLE	VASTPSST	DEG_SCF_FBW7_1	0.6765
p.P437L	ACH-000861	Lung Cancer	CCLE	VASTPSST	DEG_SCF_FBW7_1	0.7582
p.P437L	ACH-000989	Colon/Colorectal Cancer	CCLE	VASTPSST	DEG_SCF_FBW7_1	0.7582
p.P437L	HOP-62	lung	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.7582
p.P437L	SNU-175	large_intestine	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.7582
p.P422S	ACH-000987	Skin Cancer	CCLE	VASTPSST	DEG_SCF_FBW7_1	0.1667
p.P422S	Mewo	skin	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.1667
p.K448R	D-423MG	central_nervous_system	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.5278
p.R440K	COLO-684	endometrium	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.3056
p.Q449H	NCI-H196	lung	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.1667
p.R449K	COLO-684	endometrium	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.1667
p.V422I	AGS	stomach	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.1667
p.K439R	D-423MG	central_nervous_system	COSMIC	VASTPSST	DEG_SCF_FBW7_1	0.7237

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASTPSST

Degron related mutations and impact score

Drug responses associated with POGZ mutations

All proteins holding degron of VASTPSST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3K3	Pogo transposable element with ZNF domain	DEG_SCF_FBW7_1	432:439	VASTPSST	FBXW7	0.9993	More...